HIGH-FRUCTOSE FEEDING ELICITS INSULIN-RESISTANCE, HYPERINSULINISM, AND HYPERTENSION IN NORMAL MONGREL DOGS
HIGH-FRUCTOSE FEEDING ELICITS INSULIN-RESISTANCE, HYPERINSULINISM, AND HYPERTENSION IN NORMAL MONGREL DOGS
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DOI：
10.1161/01.hyp.23.4.456
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发表时间：
1994-04-01
期刊：
影响因子：
8.3
通讯作者：
ROMERO, JC
中科院分区：
文献类型：
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作者：
MARTINEZ, FJ;RIZZA, RA;ROMERO, JC
为了确定长期喂食高果糖是否会导致正常狗的胰岛素抵抗和高血压，我们给10只雄性狗喂了20-28天的正常饮食，其中60%的卡路里是果糖；8只狗的对照组喂以类似的含有葡萄糖而不是果糖的饮食。果糖组：(1)25天后空腹甘油三酯水平由35.3+/-0.63升至91.9+/-11.55 mg/dL(P
To determine whether chronic high-fructose feeding causes insulin resistance and hypertension in normal dogs, we fed 10 male dogs a normosodic diet containing 60% of the calories as fructose for 20 to 28 days; a control group of 8 dogs was fed a similar diet containing dextrose instead of fructose. In the fructose-fed group, (1) fasting triglyceridemia increased from 35.3+/-0.63 to 91.9+/-11.55 mg/dL after 25 days (P