The influence of isoflurane on the synaptic activity of 5-hydroxytryptamine.
The influence of isoflurane on the synaptic activity of 5-hydroxytryptamine.
复制标题
异氟烷对5-羟色胺突触活性的影响。
DOI：
10.1007/bf00965741
复制
发表时间：
1990
影响因子：
4.4
通讯作者：
Aronstam,RS
中科院分区：
文献类型：
--
作者：
Martin,DC;Adams,RJ;Aronstam,RS
The effects of isoflurane on uptake of 5-hydroxytryptamine(serotonin; 5-HT) by rat brain synaptosomes and binding of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and ketanserin to 5-HT1Aand 5-HT2receptors were examined. Isoflurane caused a concentration-dependent decrease in synaptosomal 5-HT uptake that was kinetically defined as non-competitive; exposure to isoflurane decreased Vmaxbut had no effect on the apparent Km. Removal of the drug from the reaction mixture resulted in the return of 5-HT accumulation rates to control levels. Isoflurane inhibited 8-OH-DPAT binding to hippocampal membranes by up to 27±6% at 4.5 mM, but did not significantly affect ketanserin binding to 5-HT2receptors. These findings suggest that presynaptic actions are more important than postsynaptic actions in the modulation of serotonergic neutrotransmission by isoflurane.
