Basal activity of the natriuretic factor extracted from the rat kidney as a function of the diet and its role in the regulation of the acute sodium balance.
Basal activity of the natriuretic factor extracted from the rat kidney as a function of the diet and its role in the regulation of the acute sodium balance.
复制标题
从大鼠肾脏提取的利尿钠因子的基础活性作为饮食的函数及其在调节急性钠平衡中的作用。
DOI：
10.1042/cs0580385
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发表时间：
1980
期刊：
影响因子：
6
通讯作者：
H. Favre
中科院分区：
文献类型：
--
作者：
F. Louis;H. Favre
1.在非扩容和扩容大鼠模型上，研究了饲料中钠含量对肾脏提取物利钠活性的影响。2.取肾组织匀浆，上清液经Sephadex G-25凝胶过滤分离。盐具有利钠活性后，洗脱出单一的低分子量组分，并在大鼠生物测定上进行测试。3.非扩张大鼠肾脏部位的利钠活性与钠摄入量有关。4.急性细胞外体积扩张后，肾脏提取物的利钠活性明显高于扩张前，且与膳食钠摄入量有关。
1. The effect of the sodium content of the diet on the natriuretic activity of an extract from the kidneys was studied in non-expanded and volume-expanded rats. 2. The kidney tissue was homogenized and the supernatant fractionated by gel filtration of Sephadex G-25. A single low-molecular-weight fraction eluted after the salt possessed the natriuretic activity and was tested on a rat bioassay. 3. The natriuretic activity of the fraction obtained from the kidneys of non-expanded rats was related to the sodium intake. 4. After an acute extracellular volume expansion, the natriuretic activity obtained from the fraction extracted from the kidneys was much greater than before expansion and was related to the dietary intake of sodium.