Enzymatic resolution of secondary alcohols coupled with ruthenium-catalyzed racemization without hydrogen mediator
Enzymatic resolution of secondary alcohols coupled with ruthenium-catalyzed racemization without hydrogen mediator
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DOI：
10.1016/s0040-4039(99)01237-x
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发表时间：
1999-08-20
影响因子：
1.8
通讯作者：
Park, J
中科院分区：
文献类型：
--
作者：
Koh, JH;Jung, HM;Park, J
发现（eta(5)-茚基）RuCl(PPh3)(2)在三乙胺和氧存在下催化仲醇外消旋。与先前报道的金属催化外消旋不同，在我们的过程中不需要酮作为氢介质。钌催化的外消旋反应与酶促乙酰化反应相结合，对仲醇进行动态动力学分解，得到收率高（60-98%）、对映选择性高（82-99% ee）的手性醋酸酯。1999爱思唯尔科学有限公司版权所有。
(eta(5)-Indenyl)RuCl(PPh3)(2) was found to catalyze the racemization of secondary alcohols in the presence of triethylamine and oxygen. Unlike previously reported metal-catalyzed racemizations, ketones were not required as hydrogen mediators in our process. The Ru-catalyzed racemization was coupled with enzymatic acetylation for the dynamic kinetic resolution of secondary alcohols to give chiral acetates in good yields (60-98%) with high enantioselectivities (82-99% ee). (C) 1999 Elsevier Science Ltd. All rights reserved.