Proton conduction through the M2 protein of the influenza A virus;: a quantitative, mechanistic analysis of experimental data
Proton conduction through the M2 protein of the influenza A virus;: a quantitative, mechanistic analysis of experimental data
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DOI：
10.1016/s0014-5793(03)00778-6
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发表时间：
2003-09-18
期刊：
影响因子：
3.5
通讯作者：
Lear, JD
中科院分区：
文献类型：
--
作者：
Lear, JD
甲型流感病毒的 M2 质子通道形成质子选择性离子通道，这是金刚烷胺药物的靶标。在这里，对现有的实验数据进行定量检查，以深入了解 M2 质子传导的 pH 值和电压依赖性的机制。分析表明，涉及 His 37 质子化平衡的模型，包括孔两侧相对扩散速率的 pH 依赖性变化，能够定量地解释最近报道的电生理数据，该数据检查 Rostock 和 Weybridge 菌株 M2 质子传导的 pH 和电压依赖性。 (C) 2003 年由 Elsevier B.V. 代表欧洲生化学会联合会出版。
The M2 proton channel from influenza A virus forms proton-selective ion channels, which are the target of the drug amantadine. Here, existing experimental data are quantitatively examined for insights into mechanisms to account for the pH-and voltage-dependences of M2 proton conduction. The analysis shows that a model involving protonation equilibria of His 37, including pH-dependent changes in the relative rates of diffusion on either side of the pore, is quantitatively able to account for recently reported electrophysiological data examining the pH-and voltage-dependences of Rostock and Weybridge strain M2 proton conduction. (C) 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.