Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
复制标题
DOI：
10.1006/bbrc.2000.3000
复制
发表时间：
2000-07-05
影响因子：
3.1
通讯作者：
Frye, RA
中科院分区：
文献类型：
--
作者：
Frye, RA
沉默调节蛋白（Sir2样蛋白）存在于原核生物和真核生物中。在此，发现两种新的人类沉默调节蛋白（SIRT6和SIRT7）与昆虫、线虫、植物和原生动物的特定沉默调节蛋白亚群相似。对来自多种生物（包括古细菌、细菌、酵母、植物、原生动物和后生动物）的60个沉默调节蛋白保守核心结构域序列进行的分子系统发育分析表明，真核生物的Sir2样蛋白分为四个主要分支，在此分别命名为I - IV类。原核生物的沉默调节蛋白包括II类和III类成员。第五类沉默调节蛋白存在于革兰氏阳性细菌和海栖热袍菌中。酿酒酵母有五个I类沉默调节蛋白。秀丽隐杆线虫和黑腹果蝇具有来自I、II和IV类的沉默调节蛋白基因。七个人类沉默调节蛋白基因涵盖了所有四类：SIRT1、SIRT2和SIRT3属于I类，SIRT4属于II类，SIRT5属于III类，SIRT6和SIRT7属于IV类。（C）2000学术出版社
Sirtuins (Sir2-like proteins) are present in prokaryotes and eukaryotes, Here, two new human sirtuins (SIRT6 and SIRT7) are found to be similar to a particular subset of insect, nematode, plant, and protozoan sirtuins. Molecular phylogenetic analysis of 60 sirtuin conserved core domain sequences from a diverse array of organisms (including archaeans, bacteria, yeasts, plants, protozoans, and metazoans) shows that eukaryotic Sir2-like proteins group into four main branches designated here as classes I-IV. Prokaryotic sirtuins include members of classes II and III. A fifth class of sirtuin is present in gram positive bacteria and Thermotoga maritima. Saccharomyces cerevisiae has five class I sirtuins. Caenorhabditis elegans and Drosophila melanogaster have sirtuin genes from classes I, II, and TV. The seven human sirtuin genes include all four classes: SIRT1, SIRT2, and SIRT3 are class I, SIRT4 is class II, SIRT5 is class III, and SIRT6 and SIRT7 are class IV. (C) 2000 Academic Press.