New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA expression in vitro
New sesquiterpene from Vietnamese agarwood and its induction effect on brain-derived neurotrophic factor mRNA expression in vitro
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DOI：
10.1016/j.bmc.2006.01.023
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发表时间：
2006-05-15
影响因子：
3.5
通讯作者：
Kadota, S
中科院分区：
文献类型：
--
作者：
Ueda, J;Imamura, L;Kadota, S
沉香是一种芳香木材，是热带森林中珍贵的非木材产品之一。它那飘逸的香味在亚洲作为仪式上的熏香以及传统医学中的镇静剂而受到珍视。从对大鼠神经细胞脑源性神经营养因子（BDNF）mRNA表达有明显诱导作用的越南沉香70%EtOH提取物中分离得到一个新化合物2-（2-苯乙基）色酮衍生物。经光谱分析，确定该化合物为香根螺烷型倍半萜，即（4 R，5 R，7 R）-1（110）-香根螺烯-11-醇-2-酮。(c)2006爱思唯尔有限公司版权所有。
Agarwood, one of the valuable non-timber products in tropical forest, is a fragrant wood. whose ethereal fragrance has been prized in Asia for incense in ceremony, as well as sedatives in traditional medicine. We separated the 70% EtOH extract of Vietnamese agarwood, which showed significant induction effect on brain-derived neurotrophic factor (BDNF) mRNA expression in rat Cultured neuronal cells, to isolate a new compound and a 2-(2-phenylethyl)chromone derivative. The new compound was determined to be a spirovetivane-type sesquiterpene, (4R,5R,7R)-1(110)-spirovetiven-11-ol-2-one, by spectroscopic data and showed induction effect of BDNF mRNA. (c) 2006 Elsevier Ltd. All rights reserved.