MELATONIN RESPONSE IN ACTIVE EPILEPSY
MELATONIN RESPONSE IN ACTIVE EPILEPSY
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DOI：
10.1111/j.1528-1157.1995.tb01669.x
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发表时间：
1995-01-01
期刊：
影响因子：
5.6
通讯作者：
MATTHEWS, CD
中科院分区：
文献类型：
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作者：
SCHAPEL, GJ;BERAN, RG;MATTHEWS, CD
尿排泄的6-硫酸氧褪黑激素（aMT.6S），褪黑激素的肝脏代谢产物，连续三个8小时的间隔，开始于0600小时，在30例未经治疗的活动性癫痫和19名健康受试者。活动性癫痫患者24小时内aMT.6S的排泄量为77.3 +/- 55 nmol（中位数68.0，范围8.7-280 nmol），显着高于（p < 0.05）健康受试者（49.1 +/- 14 nmol，中位数49.0，范围19.7-68.0 nmol）。活动性癫痫患者连续8小时尿aMT.6S排泄率为2.45 ± 2.8 nmol/h（0600-1400 h），0.83 +/- 0.5 nmol（1400-2200 h）和6.38 +/- 5.0 nmol/h（2200-0600 h），而健康受试者分别为1.43 +/- 0.8、1.10 +/- 0.8和3.81 +/- 1.3 nmol/h。方差分析（ANOVA）表明，总产量的差异是由于夜间排泄量更大（F = 5.58，p = 0.018）。与正常人相比，未经治疗的活动性癫痫患者的褪黑激素产生增加，并且具有具有相位差的昼夜节律模式。
Urinary excretion of 6-sulfatoxymelatonin (aMT.6S), the hepatic metabolite of melatonin, was measured for three consecutive 8-h intervals, beginning at 0600 h, in 30 patients with untreated active epilepsy and in 19 healthy subjects. Excretion of aMT.6S in a 24-h period in patients with active epilepsy was 77.3 +/- 55 nmol (median 68.0, range 8.7-280 nmol), significantly higher (p < 0.05) than that of healthy subjects (49.1 +/- 14 nmol, median 49.0, range 19.7-68.0 nmol). Sequential 8-h urinary aMT.6S excretion rates in patients with active epilepsy were 2.45 +/- 2.8 nmol/h (0600-1400 h), 0.83 +/- 0.5 nmol (1400-2200 h) and 6.38 +/- 5.0 nmol/h (2200-0600 h) as compared with 1.43 +/- 0.8, 1.10 +/- 0.8 and 3.81 +/- 1.3 nmol/h, respectively, in healthy subjects. Analysis of variance (ANOVA) indicated that the difference in total output resulted from greater nocturnal excretion (F = 5.58, p = 0.018). Melatonin production in untreated patients with active epilepsy is increased and has a circadian pattern with a phase difference as compared with that of normal subjects.