Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor.
Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor.
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DOI：
10.1056/nejm200104053441404
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发表时间：
2001-04-05
影响因子：
158.5
通讯作者：
Demetri, GD
中科院分区：
文献类型：
--
作者：
Joensuu, H;Roberts, PJ;Demetri, GD
胃肠道间质瘤是由胃肠道结缔组织细胞的前体细胞产生的一组间叶肿瘤。1它们主要发生在中年和老年人中，大约70%的肿瘤发生在胃中，20%至30%发生在小肠中，在胃肠道其他部位发现的少于10%。1最近的研究表明，胃肠道间质瘤细胞表达一种具有酪氨酸激酶活性的生长因子受体，称为c-kit。这种受体是原癌基因c-kit的产物，可以通过免疫组织化学染色检测到。
Gastrointestinal stromal tumors are a group of mesenchymal neoplasms that arise from precursors of the connective-tissue cells of the gastrointestinal tract.1They occur predominantly in middle-aged and older persons, and approximately 70 percent of the tumors are found in the stomach, 20 to 30 percent are found in the small intestine, and less than 10 percent are found elsewhere in the gastrointestinal tract.1Recent studies have shown that cells in gastrointestinal stromal tumors express a growth factor receptor with tyrosine kinase activity termed c-kit. This receptor, the product of the proto-oncogene c-kit,can be detected by immunohistochemical staining for . . .