Evolution of pattern of injury and quantitative MRI on days 1 and 3 in term newborns with hypoxic-ischemic encephalopathy
Evolution of pattern of injury and quantitative MRI on days 1 and 3 in term newborns with hypoxic-ischemic encephalopathy
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DOI：
10.1038/pr.2013.69
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发表时间：
2013-07-01
影响因子：
3.6
通讯作者：
Miller, Steven P.
中科院分区：
文献类型：
--
作者：
Gano, Dawn;Chau, Vann;Miller, Steven P.
背景：足月新生儿缺氧缺血性脑病（HIE）的脑损伤在第3天出现在磁共振成像（MRI）上。本研究旨在解决的关系，磁共振成像，扩散张量成像（DTI），磁共振波谱成像（MRSI）的结果在第1天和第3天在一个前瞻性队列的足月新生儿HIE.METHODS：共24例足月新生儿与HIE进行了前瞻性研究与MRI的第1天和第3天，19日与DTI和MRSI成像的第1天和第3天。使用经验证的评分评估MRI。MRI，DTI，和MRSI值之间的关系，在第1天和第3天使用线性回归重复measures.Results：常规MRI显示了复杂的变化，从第1天到第3天的结果。在灰质中，第1天测量的平均扩散率（D-av）和代谢物比率可预测第3天的值（均P
BACKGROUND: Brain injury in term neonatal hypoxic ischemic encephalopathy (HIE) emerges on magnetic resonance imaging (MRI) by day 3. This study aimed to address the relationship of MRI, diffusion tensor imaging (DTI), and MR spectroscopic imaging (MRSI) findings on days 1 and 3 in a prospective cohort of term newborns with HIE.METHODS: A total of 24 term newborns with HIE were prospectively studied with MRI on days 1 and 3; 19 were imaged with DTI and MRSI on days 1 and 3. MRI was assessed using validated scores. The relationship between MRI, DTI, and MRSI values on days 1 and 3 was determined using linear regression for repeated measures.RESULTS: Conventional MRI showed a complex variation of findings from day 1 to 3. In gray matter, mean diffusivity (D-av) and metabolite ratios measured on day 1 were predictive of values on day 3 (all P