Early Life Adversity Is Associated With Elevated Levels of Circulating Leptin, Irisin, and Decreased Levels of Adiponectin in Midlife Adults
Early Life Adversity Is Associated With Elevated Levels of Circulating Leptin, Irisin, and Decreased Levels of Adiponectin in Midlife Adults
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DOI：
10.1210/jc.2013-3669
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发表时间：
2014-06-01
影响因子：
5.8
通讯作者：
Mantzoros, Christos S.
中科院分区：
文献类型：
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作者：
Joung, Kyoung Eun;Park, Kyung-Hee;Mantzoros, Christos S.
背景：早期生活逆境，定义为18岁之前的身体、情感或性虐待和忽视，与成年后的代谢综合征、肥胖症和2型糖尿病有关。然而，潜在的机制还不完全清楚，脂肪肌动蛋白是否与早期生活逆境有关还不清楚，独立于其他因素，如体重指数、心理社会风险和健康行为。目的：该研究的目的是评估早期生活逆境与循环中脂肪肌动蛋白水平之间的关系，如瘦素、脂联素、虹膜蛋白和炎症标记物C-反应蛋白(CRP)。设计/对象/背景：这项研究是一项在大学研究中心对95名成年人进行的横断面研究。采集受试者的静脉血，分析血清瘦素、脂联素、虹膜蛋白和CRP水平。结果：最高逆境三重组的循环瘦素、虹膜凝集素和C反应蛋白水平显著高于低逆境三重体组和中三重体重组(P<；.001，P=.01，P=0.02)。高三胎组的脂联素水平低于低三胎组和中三胎组(P=0.03)。在调整了人口统计变量、体力活动、饮食、目前的精神健康状况和体重指数后，早期生活逆境中的瘦素、虹膜素和体重指数之间的关系没有改变。结论：早期生活逆境与循环瘦素和虹膜蛋白升高直接相关，与C反应蛋白升高和脂联素降低间接相关。这些发现表明，这些脂肪肌动蛋白可能在早期有明显生活逆境的人群中代谢异常的发病机制中起作用。
Context: Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known.Objectives: The objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP).Design/Subjects/Setting: This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP.Results: Circulating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P < .001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity.Conclusion: Early-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity.