Conformable and robust microfluidic force sensors to enable precision joint replacement surgery
Conformable and robust microfluidic force sensors to enable precision joint replacement surgery
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DOI：
10.1016/j.matdes.2022.110747
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发表时间：
2022-05-26
影响因子：
8.4
通讯作者：
Kar-Narayan, Sohini
中科院分区：
文献类型：
--
作者：
Ives, Liam;Pace, Alizee;Kar-Narayan, Sohini
在关节置换术期间平衡承重关节（如髋关节）内的力对于植入物的寿命至关重要。最大限度地减少植入物失效以及相应的昂贵和困难的翻修手术需求对于提高患者的生活质量和减轻过度紧张的医疗保健系统的负担至关重要。然而，在全髋关节置换术期间平衡力目前是主观的并且完全取决于手术技巧，因为目前市场上没有能够在髋关节的小且复杂的几何形状内提供定量力反馈的传感器。在这里，我们通过提出一种与标准手术程序兼容的薄且适形的微流体力传感器来解决这种未满足的临床需求。传感器通过增材制造，使用3D和气溶胶喷射打印的组合来制造。我们使用有限元建模优化了设计，然后在3D打印的髋关节植入物模型中整合并校准了我们的传感器。使用定制的测试装置，我们证明了在髋关节置换术后所经历的典型力下的高灵敏度。我们预计这些传感器将有助于软组织平衡和植入物定位，从而延长髋关节置换术的寿命。因此，这些传感器代表了一个强大的新的外科手术工具，用于一系列骨科手术，其中平衡力是至关重要的。(c)2022作者。由爱思唯尔有限公司出版。这是一篇开放获取的文章，使用CC BY许可证（http：//creativecommons.org/licenses/by/4.0/）。
Balancing forces within weight-bearing joints such as the hip during joint replacement is essential for implant longevity. Minimising implant failure and the corresponding need for expensive and difficult revision surgery is vital to both improve the quality of life of the patient and lighten the burden on over-stretched healthcare systems. However, balancing forces during total hip replacements is currently sub-jective and entirely dependent on surgical skill, as there are no sensors currently on the market that are capable of providing quantitative force feedback within the small and complex geometry of the hip joint. Here, we solve this unmet clinical need by presenting a thin and conformable microfluidic force sensor, which is compatible with the standard surgical procedure. The sensors are fabricated via additive man-ufacturing, using a combination of 3D and aerosol-jet printing. We optimised the design using finite ele-ment modelling, then incorporated and calibrated our sensors in a 3D printed model hip implant. Using a bespoke testing rig, we demonstrated high sensitivity at typical forces experienced following implantation of hip replacements. We anticipate that these sensors will aid soft tissue balancing and implant positioning, thereby increasing the longevity of hip replacements. These sensors thus represent a powerful new surgical tool for a range of orthopaedic procedures where balancing forces is crucial.(c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).