Incidence and mortality of testicular and prostatic cancers in relation to world dietary practices
Incidence and mortality of testicular and prostatic cancers in relation to world dietary practices
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DOI：
10.1002/ijc.10185
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发表时间：
2002-03-10
影响因子：
6.4
通讯作者：
Sato, A
中科院分区：
文献类型：
--
作者：
Ganmaa, D;Li, XM;Sato, A
使用国际癌症研究机构 (IARC) 提供的癌症发病率 (1988-92 年) 和粮食及农业组织 (FAO) 提供的食品供应数据 (1961-90 年)，将 42 个国家的睾丸癌和前列腺癌的发病率和死亡率与这些国家的饮食习惯相关。在我们检查的食品中，奶酪与 20-39 岁睾丸癌的发病率关系最为密切，其次是动物脂肪和牛奶。当计算 1961-65 年期间消耗的奶酪（母亲或青春期前消耗）时，相关系数 (r) 最高 (r = 0.804)。逐步多元回归分析显示，牛奶+奶酪（1961-65）对睾丸癌的发病率有显着贡献（标准化回归系数[R] = 0.654）。关于前列腺癌，牛奶（1961-90）与其发病率最密切相关（r = 0.711），其次是肉类和咖啡。逐步多重回归分析确定牛奶+奶酪是导致前列腺癌发病的一个因素（R = 0.525）。与前列腺癌死亡率关系最密切的食物是牛奶（r = 0.766），其次是咖啡、奶酪和动物脂肪。逐步多重回归分析显示，牛奶+奶酪是导致前列腺癌死亡率的一个因素（R = 0.580）。我们的研究结果表明牛奶和乳制品在睾丸癌和前列腺癌的发生和生长中发挥着作用。奶酪与睾丸癌以及牛奶与前列腺癌之间的密切相关性表明，应该对男性生殖器官癌症的发展进行进一步的机制研究。 (C) 2002 Wiley-Liss, Inc.
The incidence and mortality rates of testicular and prostatic cancers in 42 countries were correlated with the dietary practices in these countries using the cancer rates (1988-92) provided by the International Agency for Research on Cancer (IARC) and the food supply data (1961-90) provided by the Food and Agriculture Organization (FAO). Among the food items we examined, cheese was most closely correlated with the incidence of testicular cancer at ages 20-39, followed by animal fats and milk. The correlation coefficient (r) was highest (r = 0.804) when calculated for cheese consumed during the period 1961-65 (maternal or prepubertal consumption). Stepwise-multiple-regression analysis revealed that milk + cheese (1961-65) made a significant contribution to the incidence of testicular cancer (standardized regression coefficient [R] = 0.654). Concerning prostatic cancer, milk (1961-90) was most closely correlated (r = 0.711) with its incidence, followed by meat and coffee. Stepwise-multiple-regression analysis identified milk + cheese as a factor contributing to the incidence of prostatic cancer (R = 0.525). The food that was most closely correlated with the mortality rate of prostatic cancer was milk (r = 0.766), followed by coffee, cheese and animal fats. Stepwise-multiple-regression analysis revealed that milk + cheese was a factor contributing to mortality from prostatic cancer (R = 0.580). The results of our study suggest a role of milk and dairy products in the development and growth of testicular and prostatic cancers. The close correlation between cheese and testicular cancer and between milk and prostatic cancer suggests that further mechanistic studies should be undertaken concerning the development of male genital organ cancers. (C) 2002 Wiley-Liss, Inc.