Gender-Specific Association between Serum Uric Acid and Incident Fundus Arteriosclerosis in Chinese Population: A Retrospective Cross-Sectional Study
Gender-Specific Association between Serum Uric Acid and Incident Fundus Arteriosclerosis in Chinese Population: A Retrospective Cross-Sectional Study
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中国人群血清尿酸与眼底动脉硬化的性别相关性：一项回顾性横断面研究
DOI：
10.1038/s41598-020-65575-z
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发表时间：
2020-05-25
影响因子：
4.6
通讯作者：
Tang, Zaixiang
中科院分区：
文献类型：
--
作者：
Liu, Qianqian;Liu, Chunxing;Tang, Zaixiang
血清尿酸（SUA）水平升高被认为是心血管疾病的危险因素，它已被发现与动脉硬化增加有关。本研究的目的是探讨健康人群中SUA与眼底动脉硬化之间的性别特异性关系。在一项回顾性横断面研究中，23474名无糖尿病和高血压的个体被纳入本研究。根据四分位数将SUA水平分为Q1至Q4四组。采用二项Logistic回归模型估计不同SUA水平的比值比和95%可信区间。采用限制性三次样条方法估计SUA与眼底动脉硬化之间的剂量-反应关系。进行亚组分析，以发现性别特异性SUA和眼底动脉硬化事件之间的关联。在男性中，调整混杂因素后，最高SUA水平与发生眼底动脉硬化的风险显著相关。Q4的OR和95%CI为1.44（1.18，1.76），Q1作为参考。特别是女性，SUA水平与眼底动脉硬化的发生率无相关性。总之，SUA水平升高与男性眼底动脉硬化的发病率相关，但与女性无关。
Elevated levels of serum uric acid (SUA) were considered to be risk factors for cardiovascular disease, it has been found to be associated with increased arteriosclerosis. The aim of this study was to explore the gender specific relationship between SUA and fundus arteriosclerosis in a healthy population. In a retrospective cross-sectional study, 23474 individuals without diabetes and hypertension were included in the present study. SUA levels were cut to four groups as Q1 to Q4, according to the quartiles. The odds ratio and 95% confidence interval of different SUA levels were estimated by a binomial logistic regression model. A restrictive cubic spline method was used to estimate the dose-response relationship between SUA and fundus arteriosclerosis. Subgroup analysis was performed to find the gender-specific association between SUA and incident fundus arteriosclerosis. In males, after adjusting for confounding factors, the highest SUA level was significantly associated with the risk of incident fundus arteriosclerosis. The OR with 95%CI for Q4 was 1.44(1.18, 1.76), Q1 as a reference. Specially, for females, SUA level was not associated with the incidence of fundus arteriosclerosis. In conclusion, elevated levels of SUA were associated with the incidence of fundus arteriosclerosis in males, but not in females.