Water-Accelerated Nickel-Catalyzed α-Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions
Water-Accelerated Nickel-Catalyzed α-Crotylation of Simple Ketones with 1,3-Butadiene under pH and Redox-Neutral Conditions
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DOI：
10.1021/acscatal.0c00019
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发表时间：
2020-04-03
期刊：
影响因子：
12.9
通讯作者：
Xing, Dong
中科院分区：
文献类型：
--
作者：
Chen, Tiantian;Yang, Haijian;Xing, Dong
本文报道了镍/NHC催化的以1，3-丁二烯为烷基化剂的简单酮的支链选择性酰基化反应。该反应是区域选择性的，并且在pH和氧化还原中性条件下操作。水被用作唯一的添加剂，这显著加速了转化。
We report a nickel/NHC-catalyzed branched-selective acrotylation of simple ketones using 1,3-butadiene as the alkylation agent. This reaction is regioselective and operated under pH and redox-neutral conditions. Water was used as the sole additive, which significantly accelerates the transformation.