Non-invasive and Non-destructive Characterization of Tissue Engineered Constructs Using Ultrasound Imaging Technologies: A Review.
Non-invasive and Non-destructive Characterization of Tissue Engineered Constructs Using Ultrasound Imaging Technologies: A Review.
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DOI：
10.1007/s10439-015-1495-0
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发表时间：
2016-03
影响因子：
3.8
通讯作者：
Wagner WR
中科院分区：
文献类型：
--
作者：
Kim K;Wagner WR
随着生物材料开发的快速扩展以及将这些进展转化为临床的努力，迫切需要非侵入性和非破坏性成像工具来及时评估原位植入物。所需的多层次信息是全面的，包括结构、机械和生物学变化，例如支架降解、机械强度、细胞浸润、细胞外基质形成和血管化等。超声成像具有非侵入性和非破坏性的固有优势，是临床前和临床应用的理想工具。本文综述了近年来国内外超声成像技术在组织工程和再生医学中的应用，并介绍了一些新兴的超声技术和利用超声的多模态方法。
With the rapid expansion of biomaterial development and coupled efforts to translate such advances toward the clinic, non-invasive and non-destructive imaging tools to evaluate implants in situ in a timely manner are critically needed. The required multilevel information is comprehensive, including structural, mechanical, and biological changes such as scaffold degradation, mechanical strength, cell infiltration, extracellular matrix formation and vascularization to name a few. With its inherent advantages of non-invasiveness and non-destructiveness, ultrasound imaging can be an ideal tool for both preclinical and clinical uses. In this review, currently available ultrasound imaging technologies that have been applied in vitro and in vivo for tissue engineering and regenerative medicine are discussed and some new emerging ultrasound technologies and multi-modality approaches utilizing ultrasound are introduced.