Gamma oscillations coordinate amygdalo-rhinal interactions during learning
Gamma oscillations coordinate amygdalo-rhinal interactions during learning
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DOI：
10.1523/jneurosci.2153-07.2007
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发表时间：
2007-08-29
影响因子：
5.3
通讯作者：
Pare, Denis
中科院分区：
文献类型：
--
作者：
Bauer, Elizabeth P.;Paz, Rony;Pare, Denis
鼻皮质通过整合和传递新皮质信息到海马体来促进记忆的形成。由于扁桃体与鼻腔之间存在着很强的相互联系，因此它们对记忆的作用很可能受到扁桃体的影响。鉴于先前的数据表明，振荡调节神经元的活动在记忆形成和回忆，我们测试的可能性，相干振荡协调杏仁-鼻腔活动在学习过程中。为此，我们进行了同时细胞外记录基底外侧杏仁核（BLA），鼻周，和内嗅活动。我们首先测试了清醒状态下BLA和鼻场活动的功率是否存在相关波动。相关的功率波动在35- 45 Hz波段最为明显。在每个结构内，放电概率随着快速振荡有节奏地波动，表明它们不是体积传导的。为了测试快速振荡是否在学习过程中协调BLA和鼻腔活动，动物接受了跟踪条件反射任务的训练，其中视觉条件刺激（CS）预测延迟后的食物奖励。CS的预测值在9d内逐渐提高。随着学习的进展，BLA和鼻皮质中的35-45 Hz功率增加，特别是在CS和延迟的后期。此外，BLA和鼻腔神经元的放电变得有节奏地夹带在当时的BLA振荡。因此，我们的数据表明，神经元之间的相互作用是由BLA-rhinal网络中的快速振荡协调的。通过将有效神经元相互作用的周期压缩在短的重复时间窗口中，这些快速振荡可以促进鼻腔相互作用和突触可塑性。
The rhinal cortices contribute to memory formation by integrating and transferring neocortical information to the hippocampus. Rhinal contributions to memory are likely influenced by the amygdala because strong reciprocal connections exist between these structures. In light of previous data showing that oscillations regulate neuronal activity during memory formation and recall, we tested the possibility that coherent oscillations serve to coordinate amygdalo-rhinal activity during learning. To this end, we performed simultaneous extracellular recordings of basolateral amygdala ( BLA), perirhinal, and entorhinal activity. We first tested whether there are correlated fluctuations in the power of BLA and rhinal field activity during the waking state. Correlated power fluctuations were most pronounced in the 35-45Hz band. Within each structure, firing probability fluctuated rhythmically with the fast oscillations, indicating that they were not volume conducted. To test whether fast oscillations coordinate BLA and rhinal activity during learning, animals were trained on a trace-conditioning task in which a visual conditioned stimulus ( CS) predicted a food reward after a delay. The predictive value of the CS was learned gradually over 9d. As learning progressed, the 35-45 Hz power increased in the BLA and rhinal cortices, particularly during the late part of the CS and delay. Moreover, the firing of BLA and rhinal neurons became rhythmically entrained by BLA oscillations at that time. Thus, our data suggest that neuronal interactions are coordinated by fast oscillations in the BLA-rhinal network. By telescoping the periods of effective neuronal interactions in short recurring time windows, these fast oscillations may facilitate rhinal interactions and synaptic plasticity.