Sinusoidal communication in liver fibrosis and regeneration.
Sinusoidal communication in liver fibrosis and regeneration.
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DOI：
10.1016/j.jhep.2016.04.018
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发表时间：
2016-09
影响因子：
25.7
通讯作者：
Gracia-Sancho J
中科院分区：
文献类型：
--
作者：
Marrone G;Shah VH;Gracia-Sancho J
蜂窝串扰是消息在单个小区内（细胞内串扰）或不同小区之间（细胞间串扰）传输的过程。肝脏微环境中的细胞间串扰对于维持正常肝功能和细胞存活至关重要。肝细胞彼此紧密连接，协同工作，并产生调节其分化和活性的分子。这篇综述总结了目前的知识，在肝纤维化的实质和非实质细胞的旁分泌通讯网络，由于慢性损伤，部分肝切除术后的再生。
Cellular crosstalk is a process through which a message is transmitted within an individual cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular crosstalk within the liver microenvironment is critical for the maintenance of normal hepatic functions and for cells survival. Hepatic cells are closely connected to each other, work in synergy, and produce molecules that modulate their differentiation and activity. This review summarises the current knowledge regarding paracrine communication networks in parenchymal and non-parenchymal cells in liver fibrosis due to chronic injury, and regeneration after partial hepatectomy.