Meroterpenoid pigments from the basidiomycete Albatrellus ovinus.
Meroterpenoid pigments from the basidiomycete Albatrellus ovinus.
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DOI：
10.1021/np300751m
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发表时间：
2013-01
影响因子：
5.1
通讯作者：
Liangyan Liu;Zheng-Hui Li;Zhi-Hui Ding;Zejun Dong;Gentao Li;Y. Li;Jikai Liu
中科院分区：
文献类型：
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作者：
Liangyan Liu;Zheng-Hui Li;Zhi-Hui Ding;Zejun Dong;Gentao Li;Y. Li;Jikai Liu
从绵羊信天翁中分离得到8个灰树脂衍生物，涉及3个新单体：信天翁甲素A-C(1-3)、3个新二聚体(分枝萜类色素)、信天翁D-F(4-6)和2个已知化合物：6a，7，8，9，10，10a-hexahydro-3，6，9-trimethyl-6-(4-methyl-3-penten-1-yl)-1，9-epoxy-6H-dibenzo[b，d]Py ran(7)和Confluentin(8)。通过广泛的光谱分析确定了它们的结构。通过比较化合物2-4的旋光度与文献报道的数据，确定化合物2-4的绝对构型为9R。信天翁F(6)是一对C-2‘异构体，其比例为1.3：1。在体外，融合蛋白(8)对四种人肿瘤细胞株HL-60、SMMC-7712、A-549和MCF-7具有较弱的细胞毒作用。
Eight grifolin derivatives, involving three new monomers, albatrelins A-C (1-3), three novel dimers (meroterpenoid pigments), albatrelins D-F (4-6), and two known ones, 6a,7,8,9,10,10a-hexahydro-3,6,9-trimethyl-6-(4-methyl-3-penten-1-yl)-1,9-epoxy-6H-dibenzo[b,d]pyran (7) and confluentin (8), were isolated from Albatrellus ovinus. Their structures were established by extensive spectroscopic analysis. The absolute configurations of compounds 2-4 were determined as 9R by comparing their optical rotations with data reported in the literature. Albatrelin F (6) was isolated as a pair of C-2' tautomers with a ratio of 1.3:1. Confluentin (8) showed weak cytotoxicity against four human tumor cell lines, HL-60, SMMC-7712, A-549, and MCF-7, in vitro.