The role of oxidative stress in the developmental origin of adult hypertension.
The role of oxidative stress in the developmental origin of adult hypertension.
复制标题
DOI：
10.1016/j.ajog.2011.03.015
复制
发表时间：
2011-08
影响因子：
9.8
通讯作者：
Longo M
中科院分区：
文献类型：
--
作者：
Ghulmiyyah LM;Costantine MM;Yin H;Tamayo E;Clark SM;Hankins GD;Saade GR;Longo M
To determine whether oxidative stress plays a role in the development of hypertension using a mouse model of fetal programming induced by endothelial nitric oxide synthase (NOS3) deficiency Homozygous NOS3 knockout and wild type (WT) mice were cross-bred producing maternal (NOS3+pat/-mat) and paternal (NOS3+mat/-pat) heterozygous offspring. RNA from liver and kidney tissues of female pups were obtained at 14 weeks of age. Relative expression of the heat shock protein-B6 (HspB6), Peroxiredoxin-3 (PeriRedox), superoxide dismutase-1 (SOD-1), Peroxisome proliferator-activated receptor gamma (PPAR-γ), nitric oxide synthase-1 (NOS1) and 2 (NOS2) were determined. In the kidneys, expression of NOS2, PeriRedox, HspB6 and SOD-1 was upregulated in NOS3+pat/-mat but not in NOS3+mat/-pat compared to WT offspring. In the liver, there were no significant differences in the expression of NOS1, NOS2, PeriRedox, SOD-1, or PPAR-γ; however, HspB6 was downregulated in both heterozygotes offspring compared with WT. The intrauterine environment alters oxidative pathways gene expression in the kidneys of offspring, which may be a mechanism in the development of adult hypertension.
登录
查看更多内容
影响因子：
2.3
作者：
Moritz, Karen M.;Bertram, John F.
通讯作者：
Bertram, John F.
DOI：
10.1152/ajpregu.00367.2004
发表时间：
2005-05-01
影响因子：
2.8
作者：
Longo, M;Jain, V;Saade, GR
通讯作者：
Saade, GR
影响因子：
6.1
作者：
BUHIMSCHI, I;YALLAMPALLI, C;GARFIELD, RE
通讯作者：
GARFIELD, RE
DOI：
10.1152/ajpregu.00227.2006
发表时间：
2007-03-01
影响因子：
2.8
作者：
Cambonie, Gilles;Comte, Blandine;Nuyt, Anne Monique
通讯作者：
Nuyt, Anne Monique
影响因子：
8.3
作者：
Usui, M;Egashira, K;Takeshita, A
通讯作者：
Takeshita, A