The role of Syk in osteoarthritis.
The role of Syk in osteoarthritis.
复制标题
Syk 在骨关节炎中的作用。
DOI：
10.1016/j.clim.2012.07.009
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Kyttaris,VasileiosC
中科院分区：
文献类型：
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作者：
Kyttaris,VasileiosC
骨关节炎(OA)是最常见的关节疾病，以各种形式影响超过20%的25岁以上人群[1]。骨性关节炎的医疗治疗在很大程度上仍然停滞不前，主要目的是减轻与疾病相关的疼痛。到目前为止，还没有成功的疾病修饰药物，部分原因是启动骨关节炎过程、传播组织损伤以及重要的引起疼痛和功能限制的确切事件链尚不清楚。从病理生理学的角度来看，骨关节炎关节的特征是骨和软骨之间的代谢异常，而且经常是炎症，尤其是滑膜区域[2]。然而，炎症反应的原因及其对骨关节组织损伤的相对贡献尚不清楚。来自滑液分析的发现表明，骨性关节炎与局部先天免疫系统激活有关[3]。作为这一系统的一部分，巨噬细胞以及传统上不被认为是免疫细胞的细胞(如软骨细胞)释放的介质会引起或增强炎症反应，从而进一步损害软骨及其下面的骨骼。
Osteoarthritis (OA) is the most common joint disease affecting in various forms more than 20% of the population above the age of 25 [1]. The medical treatment of OA has largely remained stagnant and mainly aims at alleviating pain associated with the disease. To date no disease modifying drugs have been successfully developed partly because the exact chain of events that initiate the osteoarthritic process, propagate tissue damage, and importantly cause pain and functional limitations are unclear.From a pathophysiological standpoint, the osteoarthritic joint is characterized by aberrant metabolism in both the bone and cartilage compartments, and oftentimes inflammation especially at the synovial area [2]. The cause of the inflammatory response, and its relative contribution to tissue damage of the osteoarthritic joint is unclear though. Findings from synovial fluid analysis suggest that OA is associated with local innate immune system activation [3]. As part of this system, macrophages but also cells that are not classically thought as immune cells such as chondrocytes release mediators that cause or augment an inflammatory response that further damages the cartilage and its underlying bone.