Lymphoma of the Skin
Lymphoma of the Skin
复制标题
皮肤淋巴瘤
DOI：
10.1111/j.1600-0560.1977.tb00897.x
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发表时间：
1977
影响因子：
1.7
通讯作者：
H. King
中科院分区：
文献类型：
--
作者：
N. Saxe;L. Kahn;H. King
皮肤淋巴瘤的临床病理研究包括真菌样肉芽肿14例，原发淋巴瘤14例，继发性淋巴瘤22例。真菌样肉芽肿具有临床和组织病理学特征，可以与其他组分开。在这项研究中，真菌样肉芽肿患者病程较长，表现为丘疹、斑块、红皮病或全身性皮炎，但从一开始就没有肿瘤结节。一个可靠的组织学诊断需要霉菌病细胞的存在，而霉菌病细胞通常与混合性炎性细胞浸润有关。另一个重要的组织学特征是真菌病细胞单独和/或在巢内(Pautrier微脓肿)侵犯表皮。皮肤原发和继发淋巴瘤的临床表现为多发性肿瘤结节，组织学表现为局限于真皮和皮下组织的单形性肿瘤细胞浸润性病变。在所有三组病例中的几个病例中，都存在相关的显著上皮样细胞反应，这一特征尚未在大型系列病例中得到充分的记录。
A clinico‐pathologic study of lymphomas of the skin included 14 cases of mycosis fungoides, 14 of primary lymphoma and 22 of secondary lymphoma. Mycosis fungoides has clinical and histopathologic features which allow for separation from the other groups. In this study, patients with mycosis fungoides had a longer duration of history and presented with papules, plaques, erythroderma or generalized dermatitis but not with tumor nodules ab initio. A confident histologic diagnosis required the presence of the mycosis cell, which was usually present in association with a mixed inflammatory cell infiltrate. Another important histologic feature was the presence of invasion of the epidermis by the mycosis cells singly and/or in nests (Pautrier microabscesses). Primary and secondary lymphomas of the skin presented clinically as multiple tumor nodules and histologically as a monomorphic infiltrate of neoplastic cells confined to the dermis and subcutis. A feature which has not been adequately documented in a large series was the presence of an associated prominent epithelioid cell reaction in several cases from all three groups.