Chiral Phosphoric Acid Catalyzed Intramolecular Dearomative Michael Addition of Indoles to Enones
Chiral Phosphoric Acid Catalyzed Intramolecular Dearomative Michael Addition of Indoles to Enones
复制标题
手性磷酸催化吲哚与烯酮的分子内脱芳迈克尔加成
DOI：
10.1021/acs.orglett.6b03610
复制
发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
You Shu-Li
中科院分区：
文献类型：
--
作者：
Zhou Yong;Xia Zi-Lei;Gu Qing;You Shu-Li
An enantioselective intramolecular dearomative Michael addition of indolyl enones is presented. In the presence of catalytic amount of chiral phosphoric acid, various enantioenriched spiro-indolenines bearing a quaternary stereogenic center were obtained with good yields and enantioselectivity (up to 97% ee) under mild reaction conditions.
