COCAINE SELF-ADMINISTRATION INCREASES PREPRODYNORPHIN, BUT NOT C-FOS, MESSENGER-RNA IN RAT STRIATUM
COCAINE SELF-ADMINISTRATION INCREASES PREPRODYNORPHIN, BUT NOT C-FOS, MESSENGER-RNA IN RAT STRIATUM
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DOI：
10.1097/00001756-199305000-00020
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发表时间：
1993-05-01
期刊：
影响因子：
1.7
通讯作者：
MCGINTY, JF
中科院分区：
文献类型：
--
作者：
DAUNAIS, JB;ROBERTS, DCS;MCGINTY, JF
采用原位杂交组织化学方法检测可卡因自我给药对纹状体前强啡肽和 c-fos mRNA 表达的影响。可卡因显着增加背侧纹状体中的前强啡肽原 mRNA，但不增加腹侧纹状体。在所有检查的结构中，施用可卡因的大鼠中c-fos mRNA的表达与对照组的表达没有差异。这些结果表明，由于可卡因自我给药，大鼠纹状体中前强啡肽原的表达上调，但 c-fos 没有上调。此外，这些数据表明，在暴露于重复剂量的可卡因的大鼠中，前强啡肽原的调节与c-fos的表达是分离的。
THE impact of cocaine self-administration on the expression of striatal preprodynorphin and c-fos mRNA was examined with in situ hybridization histochemistry. Cocaine significantly increased preprodynorphin mRNA in the dorsal, but not ventral, striatum. Expression of c-fos mRNA in cocaine-administering rats did not differ from that in controls in all structures examined. These results indicate that the expression of preprodynorphin, but not c-fos, is upregulated in rat striatum as a consequence of cocaine self-administration. Furthermore, these data indicate that the regulation of preprodynorphin is dissociable from the expression of c-fos in rats exposed to repeated doses of cocaine.