VETSA: The Vietnam Era Twin Study of Aging
VETSA: The Vietnam Era Twin Study of Aging
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DOI：
10.1017/thg.2012.86
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发表时间：
2013-02-01
影响因子：
0.9
通讯作者：
Lyons, Michael J.
中科院分区：
文献类型：
--
作者：
Kremen, William S.;Franz, Carol E.;Lyons, Michael J.
越南时代双胞胎衰老研究（VETSA）是一项纵向行为遗传学研究，主要关注男性的认知和大脑衰老。它包括来自越南时代双胞胎登记处的1,200多对双胞胎的子集。与许多其他衰老研究一样，VETSA包括许多不同的表型，但有一些关键特征将其与大多数其他行为遗传衰老研究区分开来。第一，最初的评估是在所有参与者都是中年人的时候进行的。其次，参与者的年龄范围很窄;在最初招募时，所有人都在50多岁。第三，这项研究包括一个广泛而苛刻的神经认知测试组合，旨在提供不同认知能力的良好覆盖，并避免中年人的天花板效应。第四，年轻人的认知测试数据（平均年龄为20岁）可用于衡量认知变化。这些特征使得VETSA非常适合研究从中年到老年的个体内轨迹的异质性，以及早期检测认知能力下降的风险因素。
The Vietnam Era Twin Study of Aging (VETSA) is a longitudinal behavioral genetic study with a primary focus on cognitive and brain aging in men. It comprises a subset of over 1,200 twins from the Vietnam Era Twin Registry. Like many other studies of aging, the VETSA includes many different phenotypes, but there are some key features that distinguish it from most other behavioral genetic aging studies. First, the initial assessment was conducted when all participants were middle-aged. Second, the age range of participants is narrow; all were in their 50s at the time of the initial recruitment. Third, the study includes an extensive and demanding neurocognitive test battery that was designed to provide good coverage of different cognitive abilities and avoid ceiling effects in middle-aged adults. Fourth, young adult cognitive test data (at an average age of 20 years) are available to provide a gauge of cognitive change. These features make the VETSA ideal for studying the heterogeneity of within-individual trajectories from midlife to old age, and for early detection of risk factors for cognitive decline.