Ras effectors
Ras effectors
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DOI：
10.1016/s0955-0674(96)80066-4
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发表时间：
1996-04-01
影响因子：
7.5
通讯作者：
Marshall, CJ
中科院分区：
文献类型：
--
作者：
Marshall, CJ
寻找与 Ras 的活性 GTP 结合形式相互作用以传递增殖、分化和肿瘤发生信号的蛋白质是一项漫长的工作。现在有几种强有力的 Ras 效应因子候选者，包括蛋白激酶、脂质激酶和鸟嘌呤核苷酸交换因子。最近获得了关于效应子中的一个 Ras 结合域如何与 Ras GTP 相互作用的结构信息。最近的数据表明，Ras 癌蛋白的转化需要激活多种信号转导途径，包括通过 GTP 酶 Rho 家族成员传递信号的途径。
The search for proteins which interact with the active GTP-bound form of Ras in order to transmit signals for proliferation, differentiation and oncogenesis has been a long one. Now there are several strong candidates for Ras effecters that include protein kinases, lipid kinases and guanine nucleotide exchange factors. Structural information on how one Ras-binding domain in an effector interacts with Ras GTP has recently been obtained. Recent data show that transformation by Ras oncoproteins requires the activation of several signal transduction pathways, including those which transmit signals via members of the Rho family of GTPases.