Bidirectional telemetry controller for neuroprosthetic devices.
Bidirectional telemetry controller for neuroprosthetic devices.
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DOI：
10.1109/tnsre.2009.2036849
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发表时间：
2010-02
期刊：
影响因子：
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通讯作者：
Pikov V
中科院分区：
文献类型：
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作者：
Sharma V;McCreery DB;Han M;Pikov V
我们提出了多功能的多功能可编程控制器与双向数据遥测，实现使用现有的商业微芯片和标准蓝牙协议，增加了方便性，可靠性和易用性的神经假体设备。控制器，重190克，被放置在动物的背部，并提供双向持续遥测速率为500 kb/s，允许实时控制刺激参数和查看采集的数据。在连续工作状态下，控制器消耗约420 mW，无需充电即可工作8 h。它具有独立的16通道电流控制刺激，允许电流转向;可定制的刺激电流波形;记录刺激电压波形和刺激伪影消隐电路诱发的神经元反应。该设备的灵活性、可扩展性、成本效益和用户友好的计算机界面允许在动物试验中用于各种神经假体应用。控制器的初步测试已在猫模型的脑干听觉假体。在该模型中，将电刺激施加到植入耳蜗腹侧核的微电极阵列上，而将电极植入对侧下丘记录诱发的神经元活动。以312 kilosamples/s的速率采集刺激电压波形以监测电极的接入阻抗。在刺激脉冲期间记录放大器的消隐（瞬时沉默）后记录下丘中诱发的神经元活动，从而允许在耳蜗核中施加的刺激脉冲结束后100 μs内检测神经元反应。
We present versatile multifunctional programmable controller with bidirectional data telemetry, implemented using existing commercial microchips and standard Bluetooth protocol, which adds convenience, reliability, and ease-of-use to neuroprosthetic devices. Controller, weighing 190 g, is placed on animal's back and provides bidirectional sustained telemetry rate of 500 kb/s, allowing real-time control of stimulation parameters and viewing of acquired data. In continuously-active state, controller consumes ∼420 mW and operates without recharge for 8 h. It features independent 16-channel current-controlled stimulation, allowing current steering; customizable stimulus current waveforms; recording of stimulus voltage waveforms and evoked neuronal responses with stimulus artifact blanking circuitry. Flexibility, scalability, cost-efficiency, and a user-friendly computer interface of this device allow use in animal testing for variety of neuroprosthetic applications. Initial testing of the controller has been done in a feline model of brainstem auditory prosthesis. In this model, the electrical stimulation is applied to the array of microelectrodes implanted in the ventral cochlear nucleus, while the evoked neuronal activity was recorded with the electrode implanted in the contralateral inferior colliculus. Stimulus voltage waveforms to monitor the access impedance of the electrodes were acquired at the rate of 312 kilosamples/s. Evoked neuronal activity in the inferior colliculus was recorded after the blanking (transient silencing) of the recording amplifier during the stimulus pulse, allowing the detection of neuronal responses within 100 μs after the end of the stimulus pulse applied in the cochlear nucleus.