Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke.
Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke.
复制标题
DOI：
10.1016/s1474-4422(10)70164-2
复制
发表时间：
2010-09
期刊：
影响因子：
48
通讯作者：
Hillis, Argye E.
中科院分区：
文献类型：
--
作者：
Gottesman, Rebecca F.;Hillis, Argye E.
中风仍然是全世界发病率的主要原因，主要是因为它对认知的影响。个人可以从中风造成的身体残疾中恢复过来，但由于认知障碍，可能无法回到以前的职业或独立生活。认知功能障碍的范围从直接由梗死区域或邻近组织灌注不足引起的局灶性缺陷到更全面的认知功能障碍。全身功能障碍可能与其他潜在的亚临床脑血管疾病有关，如白质疾病或亚临床梗死。脑卒中后认知功能障碍的研究由于定义不同和缺乏脑卒中前认知测量而变得复杂。此外，中风可影响白质连通性，因此新的成像技术，如弥散张量成像和磁化转移成像，可用于评估这种亚临床损伤，是评估中风后认知功能障碍的重要工具。随着研究越来越关注可预防的危险因素在痴呆发展中的作用，卒中在认知障碍和痴呆发展中的作用可能成为预防的另一个目标。
Stroke remains a primary cause of morbidity throughout the world mainly because of its effect on cognition. Individuals can recover from physical disability resulting from stroke, but might be unable to return to their previous occupations or independent life because of cognitive impairments. Cognitive dysfunction ranges from focal deficits, resulting directly from an area of infarction or from hypoperfusion in adjacent tissue, to more global cognitive dysfunction. Global dysfunction is likely to be related to other underlying subclinical cerebrovascular disease, such as white-matter disease or subclinical infarcts. Study of cognitive dysfunction after stroke is complicated by varying definitions and lack of measurement of cognition before stroke. Additionally, stroke can affect white-matter connectivity, so newer imaging techniques, such as diffusion-tensor imaging and magnetisation transfer imaging, that can be used to assess this subclinical injury are important tools in the assessment of cognitive dysfunction after stroke. As research is increasingly focused on the role of preventable risk factors in the development of dementia, the role of stroke in the development of cognitive impairment and dementia could be another target for prevention.