PLATELET SURVIVAL AND THE DEVELOPMENT OF CORONARY-ARTERY DISEASE IN THE YOUNG-ADULT - EFFECTS OF CIGARETTE-SMOKING, STRONG FAMILY HISTORY AND MEDICAL THERAPY
PLATELET SURVIVAL AND THE DEVELOPMENT OF CORONARY-ARTERY DISEASE IN THE YOUNG-ADULT - EFFECTS OF CIGARETTE-SMOKING, STRONG FAMILY HISTORY AND MEDICAL THERAPY
复制标题
DOI：
10.1161/01.cir.63.3.546
复制
发表时间：
1981-01-01
期刊：
影响因子：
37.8
通讯作者：
ELVEBACK, LR
中科院分区：
文献类型：
--
作者：
FUSTER, V;CHESEBRO, JH;ELVEBACK, LR
年龄在50岁以下的50名有症状的冠心病患者中，有46人吸烟或有强烈的冠心病家族史。在这些患者中，60%的患者有51Cr记录的血小板存活半衰期缩短(<；92h)，在吸烟或有强烈冠心病家族史的同龄明显正常的人中，有56%的人记录到了缩短的血小板存活半衰期(<；92h)，而在不吸烟和没有家族史的正常人中，只有14%的人记录到了51cr(P<；0.01)。服用潘生丁加阿司匹林的冠心病患者和戒烟后明显正常的吸烟者，其缩短的血小板存活期延长至正常(P<；0.01)。吸烟、冠心病家族史和血小板活化在青年冠状动脉粥样硬化形成过程中可能存在联系。
Cigarette smoking or a strong family history of coronary disease was present in 46 of 50 symptomatic patients with coronary artery disease who were younger than 50 yr of age. A shortened platelet survival half-life (< 92 h) was recorded with 51Cr in 60% of these patients, in 56% of apparently normal persons of the same age who smoked or had a strong family history of coronary disease and in only 14% of normal persons who did not smoke and had no family history (P < 0.01). Lengthening of the shortened platelet survival toward normal occurred in coronary patients given dipyridamole plus aspirin and in apparently normal smokers who discontinued smoking (P < 0.01). A possible relationship exists among cigarette smoking, strong family history of coronary disease and platelet activation in the process of coronary atherogenesis in the young adult.