Endoplasmic Reticulum Stress and the Unfolded Protein Response
Endoplasmic Reticulum Stress and the Unfolded Protein Response
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DOI：
10.1016/j.cld.2009.07.004
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发表时间：
2009-11-01
影响因子：
5.1
通讯作者：
Sanyal, Arun J.
中科院分区：
文献类型：
--
作者：
Kapoor, Ashwani;Sanyal, Arun J.
内质网（ER）是参与蛋白质稳态的关键细胞器。未折叠蛋白反应（unfolded protein response，UPR）是由于缺乏ATP或原发性内质网功能障碍而引起的内质网应激所引发的一个基本细胞过程。UPR在非酒精性脂肪肝（NAFLD）中被激活和失调。UPR已被证明参与正常的生理功能和对许多病理状态的细胞反应。本文综述了普遍定期审议的途径及其在NAFLD发生和发展中的潜在作用。
The endoplasmic reticulum (ER) is the key cellular organelle involved in protein homoeostasis. The unfolded protein response (UPR) is a fundamental cellular process triggered by ER stress because of lack of ATP or primary ER dysfunction. The UPR is activated and dysregulated in non-alcoholic fatty liver disease (NAFLD). The UPR has been shown to be involved in both normal physiologic functions and the cellular response to a host of pathologic states. This article reviews the pathways by which the UPR unfolds and its potential role in the development and progression of NAFLD.