A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients
A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients
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DOI：
10.1364/oe.18.005580
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发表时间：
2010-03-15
期刊：
影响因子：
3.8
通讯作者：
Wilson, Brian C.
中科院分区：
文献类型：
--
作者：
Kim, Anthony;Roy, Mathieu;Wilson, Brian C.
组织光吸收和（传输）约化散射系数（分别为μ（α）和μ（ε ′））的测量是光在医学和生物学中的许多应用的基础。我们报告了一个手持光纤探头，以确定这些系数，通过测量漫反射在多个源-集热器的距离，它允许一个更大的动态范围比一个单一的源-集热器分离。漫反射率的前向模型中使用了扩散理论和μ（a）和μ（s）'的光谱形状的先验知识。利用蒙特卡罗模拟、体模实验和活体组织对该方法的动态范围和准确性进行了评价。(C)2010年美国光学学会
Measurement of tissue optical absorption and (transport) reduced scattering coefficients (mu(a) and mu(s)', respectively) is fundamental to many applications of light in medicine and biology. We report a handheld fiberoptic probe to determine these coefficients by measuring the diffuse reflectance at multiple source-collector distances, which allows for a larger dynamic range than a single source-collector separation. Diffusion theory and a priori knowledge of the spectral shape of mu(a) and mu(s)' are used in a forward model of the diffuse reflectance. The dynamic range and accuracy of this method were evaluated using Monte Carlo simulations, phantom experiments and tissues in vivo. (C) 2010 Optical Society of America