Risk assessment and prognostic factors for mould-related diseases in immunocompromised patients
Risk assessment and prognostic factors for mould-related diseases in immunocompromised patients
复制标题
DOI：
10.1093/jac/dkq437
复制
发表时间：
2011-01-01
影响因子：
5.2
通讯作者：
Blijlevens, Nicole
中科院分区：
文献类型：
--
作者：
Pagano, Livio;Akova, Murat;Blijlevens, Nicole
侵袭性真菌病是免疫功能低下患者发病和死亡的重要原因。血液系统恶性肿瘤和实体癌患者，以及接受异基因造血干细胞和实体器官移植的患者，发生此类感染的风险很高。许多真菌可引起侵袭性疾病，曲霉属。和念珠菌属（Candida spp.）是感染易感患者的流行真菌病原体。在过去几年中，稀有霉菌（例如接合菌和镰刀菌）已经成为临床疾病的主要原因。这篇综述旨在分析与免疫系统受损相关的环境因素和参数，这些因素和参数被认为有利于侵袭性霉菌感染的发生。有些霉菌在所有类型的患者中都很常见，而另一些霉菌似乎仅限于特定的患者子集，如异基因造血干细胞或实体器官移植受者。除了探索使患者易患侵袭性霉菌感染的因素外，还确定了有助于预测这些感染最终结果的预后因素。
Invasive fungal diseases are important causes of morbidity and mortality in immunocompromised patients. Patients with haematological malignancies and solid cancers, as well as those with allogeneic haematopoietic stem cell and solid organ transplants, are at high risk of developing such an infection. Many fungi can cause invasive disease, with Aspergillus spp. and Candida spp. being the prevalent fungal pathogens infecting susceptible patients. During the past few years, rare moulds (for example Zygomycetes and Fusarium spp.) have come into focus as the cause of devastating clinical disease. This review aims to analyse environmental factors and parameters related to impairment of the immune system that are thought to favour the onset of invasive mould infections. Some moulds are quite common among all categories of patients, while others appear to be limited to a given subset of patients, such as allogeneic haematopoietic stem cell or solid organ transplant recipients. In addition to an exploration of factors that predispose patients to the acquisition of an invasive mould infection, prognostic factors that help to predict the eventual outcome of these infections are identified.