Both clonidine and metoprolol modify anesthetic depth indicators and reduce intraoperative propofol requirement
Both clonidine and metoprolol modify anesthetic depth indicators and reduce intraoperative propofol requirement
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DOI：
10.1007/s00540-007-0606-y
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发表时间：
2008-05-01
影响因子：
2.8
通讯作者：
Prabhakar, Hemanshu
中科院分区：
文献类型：
--
作者：
Ghosh, Indranil;Bithal, Parmod K.;Prabhakar, Hemanshu
目的.过去曾使用β受体阻滞剂来降低麻醉深度，但结果相互矛盾。然而，已知β受体阻滞剂抑制脑电图活动。本研究旨在评估美托洛尔对麻醉深度指标的影响。我们还比较了美托洛尔在减少丙泊酚需要量方面的作用。90例接受周围神经损伤修复的健康成人患者被纳入三组，在手术前1小时接受：含可乐定200 μ g的片剂、含酒石酸美托洛尔100 mg的片剂或安慰剂。遵循标准麻醉技术。监测脑电双频指数以指导丙泊酚输注，并维持在40至60之间。记录麻醉和手术的总时间以及丙泊酚的总用量。所有三组的人口统计学变量具有可比性。可乐定组和美托洛尔组丙泊酚用量明显少于安慰剂组（P < 0.001）。与其他两组相比，安慰剂组的心率和平均血压值差异显著。我们的研究表明，与可乐定一样，美托洛尔减弱了术中刺激的血流动力学反应，并且对丙泊酚剂量要求也有节约作用。
Purpose. Beta-blockers have been used in the past to decrease the depth of anesthesia, but the results are conflicting. However, beta-blockers are known to suppress electroencephalographic activities. This study was carried out to assess the effect of metoprolol on anesthetic depth indicators. We also compared the effect of metoprolol in reducing propofol requirements.Methods. Ninety healthy adult patients undergoing peripheral nerve injury repair were enrolled in three groups to receive either: a tablet containing clonidine 200 mu g, a tablet containing metoprolol tartrate 100 mg, or a placebo; 1 h prior to surgery. Standard anesthesia technique was followed. The bispectral index was monitored to guide propofol infusion and was maintained between 40 and 60. The total duration of anesthesia and surgery, and the total propofol consumption, were noted.Results. Demographic variables were comparable in all three groups. Significantly less propofol was consumed by patients in the clonidine and metoprolol groups in comparison to that in the placebo group (P < 0.001). Heart rate and mean blood pressure values differed significantly in the placebo group in comparison to the values in the other two groups.Conclusion. Our study showed that, like clonidine, metoprolol attenuated the hemodynamic response to intraoperative stimuli and also had a sparing effect on the propofol dose requirement.