Chemopreventive effects of beta-carotene and 13-cis-retinoic acid on salivary gland tumors.
Chemopreventive effects of beta-carotene and 13-cis-retinoic acid on salivary gland tumors.
复制标题
β-胡萝卜素和 13-顺式-视黄酸对唾液腺肿瘤的化学预防作用。
DOI：
10.1080/01635588509513801
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
W. Gibson
中科院分区：
文献类型：
--
作者：
B. S. Alam;S. Q. Alam;J. Weir;W. Gibson
本文研究了β-胡萝卜素和13-顺式维甲酸（RA）对化学诱发的大鼠涎腺肿瘤的化学预防作用。将溶解于橄榄油中的1 mg二甲基苯并蒽（DMBA）注射到年轻雄性Sprague-Dawley大鼠的一个下颌下唾液腺中。对侧腺体单独注射溶剂。将大鼠分为4组，自由采食添加0或100 mg β-胡萝卜素/kg饲料或20或100 mg RA/kg饲料的半合成饲料。在DMBA处理后22周处死大鼠，并对肿瘤进行组织学检查。肿瘤通常为鳞状细胞癌或类似鳞状细胞癌的低分化肿瘤。在喂食补充β-胡萝卜素的饮食的大鼠中，肿瘤发生率略低。RA对肿瘤发生率无明显影响。组织化学显示肿瘤中γ-谷氨酰转肽酶的高活性。在β-胡萝卜素和RA补充组中有一些死亡率，特别是在高水平RA喂养的组中。这种死亡率似乎与维生素K变得有些有限有关。
The chemopreventive effects of beta-carotene and 13-cis-retinoic acid (RA) on chemically induced salivary gland tumors were studied in rats. Young male Sprague-Dawley rats were injected in one of the submandibular salivary glands with 1 mg of dimethylbenzanthracene (DMBA) dissolved in olive oil. The contralateral gland was injected with the vehicle alone. Rats were divided into four groups and were fed ad libitum a semisynthetic diet supplemented with 0 or 100 mg beta-carotene/kg diet, or 20 or 100 mg RA/kg diet. Rats were killed at 22 weeks after the DMBA treatment, and tumors were examined histologically. Tumors were generally found to be squamous cell carcinomas or poorly differentiated neoplasms resembling squamous cell carcinomas. The tumor incidence was slightly lower in rats fed the diet supplemented with beta-carotene. RA had no appreciable effect on tumor incidence. A high activity of gamma-glutamyl transpeptidase was histochemically demonstrated in the tumors. There were some mortalities in the beta-carotene and RA supplemented groups, especially in the group fed high levels of RA. This mortality appeared to be related to vitamin K becoming somewhat limited.