Preferential distribution of inhbititory cardiac receptors in left ventricle of the dog.
Preferential distribution of inhbititory cardiac receptors in left ventricle of the dog.
复制标题
抑制性心脏受体优先分布在狗的左心室。
DOI：
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发表时间：
1978
影响因子：
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通讯作者：
H. Klopfenstein
中科院分区：
文献类型：
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作者：
J. L. Walker;M. Thames;F. Abboud;A. Mark;H. Klopfenstein
本研究的目的是确定左心室感觉末梢介导的反射效应的相对大小，该反射效应是通过向狗的左前降支（LAD）或回旋支（Cx）冠状动脉冠状动脉内注射尼古丁或藜芦碱而激活的。与向 LAD 注射相同剂量后观察到的结果相比，向 Cx 注射尼古丁或藜芦定始终导致心率、动脉压和股薄肌灌注压下降幅度更大。迷走神经切断术消除了对冠状动脉内尼古丁或藜芦定的心脏抑制和血管抑制反应。 LAD 或 Cx 灌注的左心室重量没有不同（分别为 43.5 +/- 1.65 和 44.5 +/- 2.2 g）。这些数据表明，与左心室前部激活相比，狗左心室下后部迷走神经传入感觉末梢的化学激活会导致更大的心脏抑制剂和血管抑制反应。此外，这些数据提供了强有力的证据，表明这些被化学激活的感觉末梢优先分布到左心室下后部。
The purpose of this study was to determine the relative magnitudes of the reflex effects mediated by sensory endings in the left ventricle activated by intracoronary injection of nicotine or veratridine into left anterior descending (LAD) or circumflex (Cx) coronary arteries in the dog. Injection of nicotine or veratridine into the Cx consistently resulted in larger decreases in heart rate, arterial pressure, and in gracilis perfusion pressure than were observed following injection of the same dose into the LAD. Vagotomy abolished the cardioinhibitory and vasodepressor responses to intracoronary nicotine or veratridine. The weight of left ventricle perfused by LAD or Cx was not different (43.5 +/- 1.65 and 44.5 +/- 2.2 g, respectively. These data indicate that chemical activation of sensory endings with vagal afferents in the inferoposterior left ventricle of the dog results in larger cardionhibitor and vasodepressor responses than result from activation of respects in the anterior left ventricle. Further, these data provide strong evidence that these sensory endings which are chemically activated are preferentially distributed to the inferoposterior left ventricle.