Clinical characteristics of laboratory confirmed positive cases of SARS-CoV-2 infection in Wuhan, China: A retrospective single center analysis
Clinical characteristics of laboratory confirmed positive cases of SARS-CoV-2 infection in Wuhan, China: A retrospective single center analysis
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DOI：
10.1016/j.tmaid.2020.101606
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发表时间：
2020-07-01
影响因子：
12
通讯作者：
Guo, Liang
中科院分区：
文献类型：
--
作者：
Huang, Yihui;Tu, Mengqi;Guo, Liang
据中国湖北省卫生健康委员会称，2019年12月，武汉首次出现多例病因不明的肺炎病例[1, 2]。不久之后，中国当局于 2020 年 1 月 7 日分离出一种新型冠状病毒 SARS-CoV-2（2019 年冠状病毒病；之前的 2019-nCoV）[3, 4]。据报道，在大多数情况下，患者接触过中国武汉的华南海鲜批发市场，传播似乎是从动物到人类的[2,5,6]。截至 2020 年 2 月 1 日，中国没有一个省份免受 SARS-CoV-2 的影响，已有 24 个国家报告了感染病例。为了明确 SARS-CoV-2 的发病机制和病理生理学，我们回顾性分析了武汉大学中南医院诊断为“2019 新型冠状病毒病（COVID-19）”的一组患者，描述了 SARS-CoV-2 实验室确诊病例的临床特征（见表1）本回顾性研究经武汉大学中南医院伦理审查委员会批准（临床伦理审批号2020015）。本研究共收集了2019年12月至2020年1月期间确诊的84例患者的信息，未接受SARS-CoV-2实验室确诊或中南医院实验室检测呈阴性的患者被排除在外。最终，本研究纳入了 34 名至少一次通过实验室检测呈 SARS-CoV-2 阳性的患者。这34例患者中，最早入院日期为2019年12月21日，最晚入院日期为2020年1月28日。患者随访至2020年1月29日，任何缺失数据均记录为未知。纳入患者的人口统计学、临床、实验室和影像学检查（包括CT和X射线）数据以及管理、治疗和预后均根据其病史获取。收集到的数据经过整理和总结。这些患者的平均年龄约为56岁，年龄范围为26岁至88岁。年龄小于40岁的患者有8例，70岁以上的患者有8例。我们的队列中没有获得年轻患者，需要进一步研究来验证儿童和青少年是否不太可能被感染。
According to the Health Commission of Hubei province, China, multiple pneumonia cases first appeared in Wuhan with unclear etiology in December 2019 [1, 2]. Soon after, a novel type of coronavirus SARS-CoV-2 (coronavirus disease 2019; previously 2019‐nCoV) was isolated by Chinese authorities on 7 January 2020 [3, 4]. It was reported that in most cases, patients were exposed to the Huanan Seafood Wholesale Market in Wuhan, China, and transmission appeared to be from animals into human [2, 5, 6]. No province in China has been exempt from the reach of the SARS-CoV-2, and 24 countries have reported cases of the infection until 1st February 2020. To make explicit the pathogenesis and pathophysiology of SARS-CoV-2, we retrospectively analyzed a cohort of patients who were diagnosed with “2019 novel coronavirus disease (COVID-19)” in the Zhongnan Hospital of Wuhan University, describing the clinical features of laboratoryconfirmed cases of SARS-CoV-2 infection.(see Table 1) This retrospective study was approved by the Zhongnan Hospital of Wuhan University's ethical review board (Clinical Ethical Approval No. 2020015). In total, the information of 84 patients who were diagnosed from December 2019 to January 2020 were collected and patients who did not undergo laboratory confirmation of SARS-CoV-2 or who were tested negative in the laboratory of Zhongnan Hospital were excluded in this research. Ultimately, 34 patients who tested positive to the SARS-CoV-2 at least once via laboratory were included in this study. Among these 34 patients, the earliest admission date was 21 December 2019 and the latest admission date was 28 January 2020. Patients were followed up to 29 January 2020, any missing data was recorded as unknown.Demographical, clinical, laboratory and imaging tests (including CT and X-ray) data as well as management, treatment, and prognosis for the included patients were acquired from their medical history. Data collected were sorted and summarized. The mean age of those patients was approximately 56 years and the range of age is from 26 to 88 years old. There were 8 patients who were younger than 40 years of age and also 8 patients who were older than or equal to 70 years of age. We didn't obtain young patients in our cohort and further research are needed to verify whether children and juvenile are of less likely to be infected.