Conditional gene genealogies under strong purifying selection.
Conditional gene genealogies under strong purifying selection.
复制标题
强纯化选择下的条件基因谱系。
DOI：
10.1093/molbev/msn209
复制
发表时间：
2008
影响因子：
10.7
通讯作者：
J. Wakeley
中科院分区：
文献类型：
--
作者：
J. Wakeley
祖先选择图，在样本中的等位基因类型的条件下，被用来获得一个限制基因的系谱过程下的强选择。在一个平衡的，两个等位基因系统与强选择，中性基因系谱预测随机样本和样本含有最多一个不利的等位基因。含有一个以上不利等位基因的样本具有与中性预测大不相同的基因谱系。然而，它们通过著名的Ewens抽样公式与中性基因谱系相关。模拟显示，随着选择强度的增加，快速收敛到有限的分析预测。这些结果扩展了软选择扫描有害等位基因的想法，并对人类致病等位基因之间多态性的解释产生了影响。
The ancestral selection graph, conditioned on the allelic types in the sample, is used to obtain a limiting gene genealogical process under strong selection. In an equilibrium, two-allele system with strong selection, neutral gene genealogies are predicted for random samples and for samples containing at most one unfavorable allele. Samples containing more than one unfavorable allele have gene genealogies that differ greatly from neutral predictions. However, they are related to neutral gene genealogies via the well-known Ewens sampling formula. Simulations show rapid convergence to limiting analytical predictions as the strength of selection increases. These results extend the idea of a soft selective sweep to deleterious alleles and have implications for the interpretation of polymorphism among disease-causing alleles in humans.
疾病相关等位基因的抽样分布。
影响因子：
3.3
作者：
Slatkin,M;Rannala,B
通讯作者：
Rannala,B