Correlation between tumor response to first-line chemotherapy and prognosis in advanced gastric cancer patients
Correlation between tumor response to first-line chemotherapy and prognosis in advanced gastric cancer patients
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DOI：
10.1093/annonc/mdl174
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发表时间：
2006-11-01
影响因子：
50.5
通讯作者：
Sasaki, Y.
中科院分区：
文献类型：
--
作者：
Ichikawa, W.;Sasaki, Y.
背景：在晚期胃癌中，肿瘤反应与预后的关系尚不清楚。方法：我们对25项随机试验中4593例晚期胃癌一线化疗患者的已发表数据进行了汇总分析。采用加权分析探讨客观缓解率（RR）与进展时间（TTP）和总生存时间（OS）之间的相关性。结果：在所有25项试验中，RR与TTP和OS之间存在中等相关性（r分别为0.49和0.45）。在未使用伊立替康、紫杉烷或奥沙利铂等新药的治疗组中，RR也与TTP和OS相关（r分别为0.56和0.47）。然而，在使用新药的治疗组中，RR与OS之间没有相关性，而RR与TTP之间存在中度相关性（r = 0.41）。结论：我们的结果表明，治疗反应与TTP和OS有关。客观反应在晚期胃癌化疗试验中作为替代指标的潜在作用值得进一步研究，特别是在使用新药治疗方面。
Background: In advanced gastric cancer, the relationship between tumor response and prognosis is far from clear.Methods: We performed a pooled analysis on published data from 4593 patients in 25 randomized trials of first-line chemotherapy for advanced gastric cancer. A weighed analysis was used to investigate the correlation between objective response rate (RR) and time to progression (TTP) and overall survival time (OS).Results: A moderate correlation was found between RR and TTP and OS (r = 0.49 and r = 0.45, respectively) in all 25 trials. In treatment arms without new drugs including irinotecan, taxanes, or oxaliplatin, RR also was associated with TTP and OS (r = 0.56 and r = 0.47, respectively). However, no association between RR and OS was found, whereas there was a moderate correlation between RR and TTP (r = 0.41) in treatment arms using new drugs.Conclusions: Our results indicated that response to treatment was related to TTP and OS. The potential role of objective response as a surrogate in chemotherapy trials of advanced gastric cancer warrants further investigation, especially with regard to treatment with new drugs.