NOP14 promotes proliferation and metastasis of pancreatic cancer cells.
NOP14 promotes proliferation and metastasis of pancreatic cancer cells.
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DOI：
10.1016/j.canlet.2012.03.010
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发表时间：
2012-09
期刊：
影响因子：
9.7
通讯作者：
Bin Zhou;Qiao Wu;Ge Chen;Taiping Zhang;Yupei Zhao
中科院分区：
文献类型：
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作者：
Bin Zhou;Qiao Wu;Ge Chen;Taiping Zhang;Yupei Zhao
胰腺癌是世界范围内恶性程度最高的癌症之一。我们描述了一个新的基因NOP14，它在PC细胞的增殖和迁移中起着重要的作用。抑制或过表达NOP14可降低或促进PC细胞在体内的运动、增殖和转移能力。同时，我们观察到与迁移相关的蛋白如E-钙粘蛋白、波形蛋白、MMP9、RhoA和P53以及与增殖有关的蛋白如MAPK3和CDK2的变化。综上所述，我们的研究为NOP14调控PC细胞的增殖和迁移提供了新的证据，并可能为临床诊断和治疗提供新的见解。
Pancreatic cancer (PC) is one of the most malignant cancers worldwide. We describe a novel gene, NOP14, which plays significant roles in PC cell proliferation and migration. Inhibition or overexpression of NOP14 expression in PC cells can reduce or promote motility, proliferation and metastatic capacity in vivo. In parallel, we observed changes in proteins related to migration, such as E-cadherin, vimentin, MMP9, RhoA and p53, along with proteins involved in proliferation, such as MAPK3 and CDK2. Taken together, our study provides new evidence for NOP14 in regulating PC cell proliferation and migration, and may provide new insights for clinical diagnosis and therapy.