Investigation of tick-borne viruses as pathogens of humans in South Africa and evidence of Dugbe virus infection in a patient with prolonged thrombocytopenia
Investigation of tick-borne viruses as pathogens of humans in South Africa and evidence of Dugbe virus infection in a patient with prolonged thrombocytopenia
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DOI：
10.1017/s0950268800052687
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发表时间：
1996-06-01
影响因子：
4.2
通讯作者：
Swanepoel, R
中科院分区：
文献类型：
--
作者：
Burt, FJ;Spencer, DC;Swanepoel, R
在调查南非病毒性出血热疑似病例的过程中，遇到了被蜱叮咬但缺乏感染克里米亚-刚果出血热（CCHF）病毒或非病毒性蜱传病原体证据的患者。通过酶联免疫测定法检测牛血清，以确定该国是否存在除CCHF以外的蜱传病毒。牛血清抗体阳性率为905/2116（42.8%）CCHF病毒，70/1358（5.2%），Dugbe，21/1358其中，羊传染病1358例（0.5%），Kadam病3例（0.5%），Chenuda病2例（0.4%）。未记录到与哈扎拉、Bahig、Bhanja、Thogoto和Dhori病毒的反应。CCHF的发现证实了先前的观察结果，即病毒在璃眼蜱属蜱的分布范围内广泛流行，而仅在蜱Amblyomma hebraeum的分布范围内检测到对Dugbe抗原的抗体活性。在3/72例确诊为CCHF感染的人类患者的血清样本中检测到内罗病毒、哈扎拉病毒、内罗毕谢尔病病毒和杜格贝病毒的交叉反应性，而1/162例其他患者的血清与杜格贝抗原单特异性反应。后一名患者患有发热性疾病伴长期血小板减少症。
In the course of investigating suspected cases of viral haemorrhagic fever in South Africa patients were encountered who had been bitten by ticks, but who lacked evidence of infection with Crimean-Congo haemorrhagic fever (CCHF) virus or non-viral tick-borne agents. Cattle sera were tested by enzyme-linked immunoassay to determine whether tick-borne viruses other than CCHF occur in the country. The prevalence of antibody in cattle sera was 905/2116 (42.8%) for CCHF virus, 70/1358 (5.2%) for Dugbe, 21/1358 (1.5%) for louping ill, 6/450 (1.3%) for West Nile, 7/1358 (0.5%) for Nairobi sheep disease, 3/625 (0.5%) for Kadam and 2/450 (0.4%) for Chenuda. No reactions were recorded with Hazara, Bahig, Bhanja, Thogoto and Dhori viruses. The CCHF findings confirmed previous observations that the virus is widely prevalent within the distribution range of ticks of the genus Hyalomma, while antibody activity to Dugbe antigen was detected only within the distribution range of the tick Amblyomma hebraeum. Cross-reactivity for the nairoviruses, Hazara, Nairobi sheer disease and Dugbe, was detected in serum samples from 3/72 human patients with confirmed CCHF infection, and serum from 1/162 other patients reacted monospecifically with Dugbe antigen. The latter patient suffered from febrile illness with prolonged thrombocytopenia.