SYSTEMIC CHLAMYDIA-TRACHOMATIS INFECTION IN MICE - A COMPARISON OF LYMPHOGRANULOMA VENEREUM AND TRACHOMA BIOVARS
SYSTEMIC CHLAMYDIA-TRACHOMATIS INFECTION IN MICE - A COMPARISON OF LYMPHOGRANULOMA VENEREUM AND TRACHOMA BIOVARS
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DOI：
10.1128/iai.48.1.78-82.1985
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发表时间：
1985-01-01
影响因子：
3.1
通讯作者：
CHEN, WJ
中科院分区：
文献类型：
--
作者：
BRUNHAM, RC;KUO, CC;CHEN, WJ
建立了沙眼衣原体生物群淋巴肉芽肿(LGV)全身感染小鼠模型。这种感染的病理特征与华支LGV感染相似，因为两者都以肉芽肿形成为特征。小鼠对LGV的再感染产生了抵抗力，这种抵抗力是基于细胞免疫机制的，因为它可以与免疫脾细胞转移，但不能与免疫血清转移。抗药性需要有活力的生物来诱导。比较LGV生物群感染与沙眼衣原体生物群感染。沙眼生物群产生类似但不太明显的微生物学和病理学特征。沙眼和LGV生物群之间的交叉免疫不如同一生物群内各血清群之间的交叉免疫明显。这种系统性沙眼衣原体感染模型将有助于探索LGV的毒力特征。
A murine model of systemic infection with C. trachomatis biovar lymphogranuloma venereum (LGV) was developed. The pathological features of this infection resemble those of huam LGV infection since both are characterized by granuloma formation. Mice developed resistance to reinfection with LGV, and this resistance was based on cellular immune mechansism since it was transferable with immune spleen cells but not with immune serum. Resistance required viable organisms for induction. LGV biovar infection and trachoma biovar infection were compared. Trachoma biovar produced similar but less marked microbiological and pathological features. Cross-immunity was less apparent between serovars from trachoma and LGV biovars than it was between serovars within the same biovar. This model of systemic C. trachomatis infection will be useful in exploring virulence features of LGV.