RECURRENT WHEEZY BRONCHITIS AND VIRAL RESPIRATORY-INFECTIONS
RECURRENT WHEEZY BRONCHITIS AND VIRAL RESPIRATORY-INFECTIONS
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DOI：
10.1136/adc.66.1.124
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发表时间：
1991-01-01
影响因子：
5.2
通讯作者：
HALONEN, P
中科院分区：
文献类型：
--
作者：
MERTSOLA, J;ZIEGLER, T;HALONEN, P
对54例1~6岁反复发作喘息性支气管炎的患者进行了3个月的前瞻性随访，以了解不同病毒呼吸道感染与喘息发作之间是否存在关联。在115例上呼吸道或下呼吸道症状中，52例(45%)诊断为病毒或肺炎支原体感染。其中34例(65%)是由冠状病毒或鼻病毒引起的。患者平均有2.1次呼吸道症状，总平均持续时间(SD)为92天中的30天。在115次发作中，有76次(66%)出现喘息，其中三分之一的患者因严重呼吸困难而入院。首次出现呼吸道感染症状后开始喘息的平均时间(SD)为43(7)小时，确诊为病毒感染的患者持续喘息3.8(4.2)天。喘息的发生与IgE介导的特应性反应、病毒学试验阳性或病毒感染期间的发热无关，但与父母吸烟和一个以上的兄弟姐妹有关。
Fifty four patients aged from 1 to 6 years who had had recurrent attacks of wheezy bronchitis were prospectively followed up for three months to find out if there was an association between different viral respiratory infections and episodes of wheezing. Of the 115 episodes of upper or lower respiratory tract symptoms, virus or Mycoplasma pneumoniae infections were diagnosed in 52 (45%). Thirty four of these (65%) were caused by coronaviruses or rhinoviruses. The patients had an average of 2.1 episodes of respiratory tract symptoms the total mean (SD) duration of which was 30 (2) days of the 92 days that followed. Wheezing occurred during 76 (66%) of the 115 episodes and during a third of these the patient was admitted to hospital because of severe dyspnoea. Wheezing started a mean (SD) of 43(7) hours after the first symptoms of respiratory infection and persisted for 3.8 (4.2) days in patients in whom virus infection was diagnosed. The incidence of wheezing was not associated with IgE mediated atopy, with positive virological tests, or with fever during virus infection, but was associated with parental smoking and more than one sibling.