COVID-19: Molecular and Cellular Response.
COVID-19: Molecular and Cellular Response.
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DOI：
10.3389/fcimb.2021.563085
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发表时间：
2021
影响因子：
5.7
通讯作者：
Adcock IM
中科院分区：
文献类型：
--
作者：
Alipoor SD;Mortaz E;Jamaati H;Tabarsi P;Bayram H;Varahram M;Adcock IM
2019年12月下旬，武汉市报告一起病原不明的病毒性肺炎中国。一种新的冠状病毒被鉴定为病原体。由于冠状病毒病2019年(新冠肺炎)在人与人之间传播和迅速传播，已迅速增加到流行规模，对人类健康构成严重威胁；已被世界卫生组织宣布为国际关注的突发公共卫生事件。本文结合对SARS冠状病毒和中东呼吸综合征相关冠状病毒的研究，综述了新冠肺炎的分子特征和免疫发病机制的研究进展，为进一步防治SARS冠状病毒感染提供参考。
In late December 2019, a vtiral pneumonia with an unknown agent was reported in Wuhan, China. A novel coronavirus was identified as the causative agent. Because of the human-to-human transmission and rapid spread; coronavirus disease 2019 (COVID-19) has rapidly increased to an epidemic scale and poses a severe threat to human health; it has been declared a public health emergency of international concern (PHEIC) by the World Health Organization (WHO). This review aims to summarize the recent research progress of COVID-19 molecular features and immunopathogenesis to provide a reference for further research in prevention and treatment of SARS coronavirus2 (SARS-CoV-2) infection based on the knowledge from researches on SARS-CoV and Middle East respiratory syndrome-related coronavirus (MERS-CoV).