Reproductive responses of male Microtus montanus to photoperiod, melatonin, and 6-MBOA.
Reproductive responses of male Microtus montanus to photoperiod, melatonin, and 6-MBOA.
复制标题
雄性山田鼠对光周期、褪黑激素和 6-MBOA 的生殖反应。
DOI：
10.1111/j.1600-079x.1990.tb00890.x
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发表时间：
1990
影响因子：
10.3
通讯作者：
Berger,PJ
中科院分区：
文献类型：
--
作者：
Gower,BA;Berger,PJ
研究了光周期、褪黑激素和自然产生的生殖刺激物6 - MBOA对雄性蒙塔纳沙鼠幼鱼生长和性成熟的影响。6‐MBOA存在于发芽草中，是该物种自然种群开始繁殖的重要环境线索。长光周期（16:8）对体、睾丸和精囊的生长有刺激作用，短光周期（8:16）对这些参数有抑制作用。通过每天下午注射松果体激素褪黑素（5 μg），也抑制了上述所有参数以及血清睾酮。6‐MBOA，通过注射（0.0001-100 μg）或饮食方式（0.1或1.0 μg/gm未筛选的饲料）给药，似乎不能提高长光周期刺激动物的成熟速度。高剂量（注射100 μg或筛选饲料1.0 μg/gm）短光周期动物体内和性腺的生长受到抑制的程度大于单独短光周期动物，血清LH降低。低剂量的这种化合物没有效果。褪黑素处理的动物在同时给予低剂量6 - MBOA包膜的chow （1.0 μg/gm未筛选的chow）时，成熟抑制较少。较高剂量的6‐MBOA （1.0 μg/gm筛选鼠粮）对阻止褪黑素的反应无效。这些结果表明1)男性em。蒙古田鼠利用光周期而不是6 - MBOA作为主要的环境线索，2)高剂量的6 - MBOA在短光周期下具有抑制作用，3)幼年雄性田鼠对外源性褪黑激素的抑制作用高度敏感，4)6 - MBOA可以部分阻止褪黑激素对生长和性成熟的抑制作用。
Juvenile maleMicrotus montanuswere examined for the effects of photoperiod, melatonin, and the naturally occurring reproductive stimulant 6‐MBOA on growth and sexual maturation. 6‐MBOA, present in sprouting grass, is an important environmental cue used for the initiation of reproduction in natural populations of this species. Long photoperiod (16:8) was stimulatory to body, testes, and seminal vesicle growth, while short photoperiod (8:16) inhibited these parameters. The pineal hormone melatonin, administered via daily afternoon injections (5 μg), was also inhibitory to all of the above parameters as well as to serum testosterone. 6‐MBOA, administered via injection (0.0001–100 μg) or dietary means (0.1 or 1.0 μg/gm unsifted chow), appeared unable to augment the rate of maturation in long‐photoperiod‐stimulated animals. When short‐photoperiod animals were treated with high doses of the compound (100 μg injected or 1.0 μg/gm sifted chow), body and gonadal growth was inhibited to a greater extent than when animals were exposed to short photoperiod alone, and serum LH was reduced. Lower doses of the compound had no effect. Melatonin‐treated animals experienced less maturational inhibition when simultaneously given a low dose of 6‐MBOA‐coated chow (1.0 μg/gm unsifted chow). A higher dose of 6‐MBOA (1.0 μg/gm sifted chow) was ineffective in preventing the response to melatonin. These results indicate that 1) maleM. montanusutilize photoperiod, rather than 6‐MBOA, as a primary environmental cue, 2) high doses of 6‐MBOA can be inhibitory under short photoperiod, 3) juvenile male voles are highly sensitive to the inhibitory effects of exogenously administered melatonin, and 4) 6‐MBOA can partially prevent the inhibitory effects of melatonin on growth and sexual maturation.