DEVELOPMENT OF THE HUMAN BRAIN - IN-VIVO QUANTIFICATION OF METABOLITE AND WATER-CONTENT WITH PROTON MAGNETIC-RESONANCE SPECTROSCOPY
DEVELOPMENT OF THE HUMAN BRAIN - IN-VIVO QUANTIFICATION OF METABOLITE AND WATER-CONTENT WITH PROTON MAGNETIC-RESONANCE SPECTROSCOPY
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DOI：
10.1002/mrm.1910300405
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发表时间：
1993-10-01
影响因子：
3.3
通讯作者：
ROSS, BD
中科院分区：
文献类型：
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作者：
KREIS, R;ERNST, T;ROSS, BD
在50名儿童中通过局部质子磁共振波谱法测量脑代谢物浓度和含水量，而在173次检查中评估短回波时间谱中的代谢物峰比。建立了两个大脑位置的正常发育的标准曲线。目前的报告提出了绝对代谢物浓度和T1和T2松弛作为年龄的函数的第一项研究。发现肌醇在出生时的光谱中占主导地位（12 mmol/kg），而胆碱是年龄较大婴儿的最强峰（2.5 mmol/kg）。肌酸和N-乙酰基在新生儿中的浓度显著低于成人（Cr：6，NA：5 mmol/kg）。NA和Cr由胎龄决定，而ml浓度与出生后年龄相关性最好。 定量H-1磁共振波谱预计将在诊断和监测婴儿的病理特别有价值，因为代谢物的比例往往是误导。
Cerebral metabolite concentrations and water content were measured by means of localized proton magnetic resonance spectroscopy in 50 children, while metabolite peak ratios in short echo time spectra were evaluated in 173 examinations. Normative curves for normal development were established for two cerebral locations. The current report presents the first study of absolute metabolite concentrations and T1- and T2-relaxation as a function of age. Myo-inositol was found dominating the spectra at birth (12 mmoles/kg), while choline is responsible for the strongest peak in older infants (2.5 mmoles/kg). Creatine and N-acetyl groups are at significantly lower concentrations in the neonate than in the adult (Cr: 6, NA: 5 mmoles/kg). NA and Cr are determined by gestational age, whereas the concentration of ml correlates best with postnatal age. Quantitative H-1 MRS is expected to be of particular value in diagnosis and monitoring of pathology in infants, since metabolite ratios are often misleading.