Local particle deposition patterns may play a key role in the development of lung cancer
Local particle deposition patterns may play a key role in the development of lung cancer
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DOI：
10.1152/japplphysiol.00527.2002
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发表时间：
2003-05-01
影响因子：
3.3
通讯作者：
Heistracher, T
中科院分区：
文献类型：
--
作者：
Balásházy, I;Hofmann, W;Heistracher, T
报告的肺癌优先发生在中央气管和当前吸入颗粒物剂量估算之间的明显差异表明，实验观察到的颗粒物在支气管分叉处的局部积聚可能在肺癌的诱发中起着关键作用。在这里，我们计算了叶-段气道分叉处的三维颗粒沉积模式，并根据沉积增强因子(定义为局部沉积密度与平均沉积密度的比率)来量化由此产生的不均匀沉积模式。我们的结果显示，位于隆突的一小部分上皮细胞可以接受大剂量的辐射，甚至可能比整个呼吸道的平均剂量高几百倍。这进一步支持了一种假设，即肿瘤病变的明显部位选择性确实可能是由于有毒颗粒物在支气管气道分叉处沉积增加所致。
The apparent discrepancy between the reported preferential occurrence of bronchial carcinomas in central bronchial airways and current dose estimates for inhaled particles suggests that experimentally observed local accumulations of particles within bronchial airway bifurcations may play a crucial role in lung cancer induction. Here, we computed three-dimensional particle deposition patterns in lobar-segmental airway bifurcations and quantified the resulting inhomogeneous deposition patterns in terms of deposition enhancement factors, which are defined as the ratio of local to average deposition densities. Our results revealed that a small fraction of epithelial cells located at carinal ridges can receive massive doses that may be even a few hundred times higher than the average dose for the whole airway. This lends further credence to the hypothesis that the apparent site selectivity of neoplastic lesions may indeed be caused by the enhanced deposition of toxic particulate matter at bronchial airway bifurcations.