Production of SV40 virus in heterokaryons of transformed and susceptible cells.
Production of SV40 virus in heterokaryons of transformed and susceptible cells.
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在转化细胞和易感细胞的异核体中生产 SV40 病毒。
DOI：
10.1073/pnas.58.4.1396
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发表时间：
1967
影响因子：
11.1
通讯作者：
R. Dulbecco
中科院分区：
文献类型：
--
作者：
J. Watkins;R. Dulbecco
Cells transformed by DXA viruses do not produce progeny of the virus that caused the transformation. However, Gerber1 and Sabin and Koch2 found that small amounts of SV40 virus are produced if SV40-transformed cells are grown together with cells able to support SV40 multiplication. A clue to the possible mechanism of this activation was provided by Gerber3 and by Koprowski and Jensen,4 who observed that more virus is produced if UV-inactivated Sendai virus is added to the cell mixture. The inactivated Sendai virus promotes cell fusion;5 it is possible, therefore, that SV40 virus is produced by heterokaryons resulting from fusion of transformed cells with virus-susceptible cells.
