GPCRdb: the G protein-coupled receptor database - an introduction.
GPCRdb: the G protein-coupled receptor database - an introduction.
复制标题
DOI：
10.1111/bph.13509
复制
发表时间：
2016-07
影响因子：
7.3
通讯作者：
Gloriam DE
中科院分区：
文献类型：
--
作者：
Munk C;Isberg V;Mordalski S;Harpsøe K;Rataj K;Hauser AS;Kolb P;Bojarski AJ;Vriend G;Gloriam DE
GPCR 构成最大的人类膜蛋白和药物靶标家族。 GPCR 药理学和晶体学的最新进展为信号转导、变构调节和偏向信号传导提供了新的思路，转化为药物设计的新机制和原则。 GPCR 数据库 GPCRdb 已为社区服务了 20 多年，最近进行了扩展，涵盖了更多跨学科的受众。本次综述旨在向新用户介绍 GPCRdb 的服务，该服务满足三个总体目的：首先，以集成、注释和结构化的方式提供参考数据，重点关注序列、结构、单点突变和配体相互作用。其次，为社区配备一套网络工具，用于快速分析结构、序列相似性、受体关系和配体靶标概况。第三，通过受体残基拓扑、系统发育关系和晶体结构统计等交互图促进传播。在此，这些服务是首次描述；为游客和导游提供了良好的使用方法。最后，我们描述了 GPCRdb 和具有相应功能的 Web 服务器交叉引用的补充数据库。
GPCRs make up the largest family of human membrane proteins and of drug targets. Recent advances in GPCR pharmacology and crystallography have shed new light on signal transduction, allosteric modulation and biased signalling, translating into new mechanisms and principles for drug design. The GPCR database, GPCRdb, has served the community for over 20 years and has recently been extended to include a more multidisciplinary audience. This review is intended to introduce new users to the services in GPCRdb, which meets three overall purposes: firstly, to provide reference data in an integrated, annotated and structured fashion, with a focus on sequences, structures, single‐point mutations and ligand interactions. Secondly, to equip the community with a suite of web tools for swift analysis of structures, sequence similarities, receptor relationships, and ligand target profiles. Thirdly, to facilitate dissemination through interactive diagrams of, for example, receptor residue topologies, phylogenetic relationships and crystal structure statistics. Herein, these services are described for the first time; visitors and guides are provided with good practices for their utilization. Finally, we describe complementary databases cross‐referenced by GPCRdb and web servers with corresponding functionality.