Improved assessment of cartilage repair tissue using fluid-suppressed 23Na inversion recovery MRI at 7 Tesla: preliminary results
Improved assessment of cartilage repair tissue using fluid-suppressed 23Na inversion recovery MRI at 7 Tesla: preliminary results
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DOI：
10.1007/s00330-012-2383-8
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发表时间：
2012-06-01
影响因子：
5.9
通讯作者：
Regatte, Ravinder R.
中科院分区：
文献类型：
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作者：
Chang, Gregory;Madelin, Guillaume;Regatte, Ravinder R.
目的 使用三维 (3D)、径向、超短回波时间 (UTE) Na-23 MR 序列评估软骨修复和天然组织，不使用或使用反转恢复 (IR) 准备脉冲以进行 7 特斯拉 (T) 的流体抑制。 方法 本研究已获得机构审查委员会的批准。我们从骨科手术诊所连续招募了 11 名接受过膝关节软骨修复手术的患者（41.5 +/- 11.8 岁）。术后（中位 = 26 周）对受试者进行 7-T MRI 检查，使用：质子-T2（TR/TE = 3,000 ms/60 ms）；钠 UTE（TR/TE = 100 ms/0.4 ms）；流体抑制、钠 UTE 绝热红外。使用外部 NaCl 模型计算修复组织 ([Na+](R))、邻近天然软骨 ([Na+](N)) 和对侧非手术隔室内的天然软骨 ([Na+](N2)) 中的软骨钠浓度。结果 对于传统钠成像，平均 [Na+](R)、[Na+](N)、[Na+](N2) 为 177.8 +/- 54.1分别为170.1+/-40.7mM、172.2+/-30mM。 [Na+](R) 与[Na+](N) (= 0.59) 以及[Na+](N) 与[Na+](N2) (= 0.89) 之间的差异不显着。对于钠红外成像，平均 [Na+](R)、[Na+](N)、[Na+](N2) 分别为 108.9 +/- 29.8 mM、204.6 +/- 34.7 mM、249.9 +/- 44.6 mM。 [Na+](R) 相对于 [Na+](N) ( = 0.0.0000035) 和 [Na+](N) 相对于 [Na+](N2) ( = 0.015) 的下降显着。 结论 7 T 钠红外成像可以抑制滑液中游离钠的信号。这可以改进对软骨修复和天然组织内 [Na+] 的评估。要点NaIR 磁共振成像可以抑制滑液内钠的信号。因此，NaIR MRI 可以单独评估软骨组织内的钠浓度。这可能有助于更准确地评估修复组织的成分和质量。
Objectives To evaluate cartilage repair and native tissue using a three-dimensional (3D), radial, ultra-short echo time (UTE) Na-23 MR sequence without and with an inversion recovery (IR) preparation pulse for fluid suppression at 7 Tesla (T).Methods This study had institutional review board approval. We recruited 11 consecutive patients (41.5 +/- 11.8 years) from an orthopaedic surgery practice who had undergone a knee cartilage restoration procedure. The subjects were examined postoperatively (median = 26 weeks) with 7-T MRI using: proton-T2 (TR/TE = 3,000 ms/60 ms); sodium UTE (TR/TE = 100 ms/0.4 ms); fluid-suppressed, sodium UTE adiabatic IR. Cartilage sodium concentrations in repair tissue ([Na+](R)), adjacent native cartilage ([Na+](N)), and native cartilage within the opposite, non-surgical compartment ([Na+](N2)) were calculated using external NaCl phantoms.Results For conventional sodium imaging, mean [Na+](R), [Na+](N), [Na+](N2) were 177.8 +/- 54.1 mM, 170.1 +/- 40.7 mM, 172.2 +/- 30 mM respectively. Differences in [Na+](R) versus [Na+](N) ( = 0.59) and [Na+](N) versus [Na+](N2) ( = 0.89) were not significant. For sodium IR imaging, mean [Na+](R), [Na+](N), [Na+](N2) were 108.9 +/- 29.8 mM, 204.6 +/- 34.7 mM, 249.9 +/- 44.6 mM respectively. Decreases in [Na+](R) versus [Na+](N) ( = 0.0.0000035) and [Na+](N) versus [Na+](N2) ( = 0.015) were significant.Conclusions Sodium IR imaging at 7 T can suppress the signal from free sodium within synovial fluid. This may allow improved assessment of [Na+] within cartilage repair and native tissue.Key PointsNaIR magnetic resonance imaging can suppress signal from sodium within synovial fluid.NaIR MRI thus allows assessment of sodium concentration within cartilage tissue alone.This may facilitate more accurate assessment of repair tissue composition and quality.