Human neutrophils and oral microbiota: a constant tug-of-war between a harmonious and a discordant coexistence.
Human neutrophils and oral microbiota: a constant tug-of-war between a harmonious and a discordant coexistence.
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DOI：
10.1111/imr.12451
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发表时间：
2016-09
影响因子：
8.7
通讯作者：
Jimenez-Flores E
中科院分区：
文献类型：
--
作者：
Uriarte SM;Edmisson JS;Jimenez-Flores E
中性粒细胞是先天宿主反应的主要组成部分，口腔微生物群与中性粒细胞相互作用的结果是口腔健康状况的关键决定因素。口腔微生物组的组成非常复杂，在健康和疾病方面存在差异。中性粒细胞不断被招募到口腔，在它们的数量或功能反应受阻的情况下，它们的保护作用突出，导致不同形式的牙周病。牙周炎是一种由微生物引起的慢性炎症性疾病，是牙周病中较为严重和不可逆的一种。这种慢性炎症性疾病是口腔细菌共生群落向更复杂的生态失调群落转变的结果。慢性炎症性传染病如牙周炎可发生，因为病原体能够逃避或使先天免疫系统失效。在这篇综述中，我们讨论了人类中性粒细胞如何与共生和非生态口腔群落相互作用；了解这一点对于提高我们对牙周病发病过程的认识至关重要。
Neutrophils are a major component of the innate host response, and the outcome of the interaction between the oral microbiota and neutrophils is a key determinant of oral health status. The composition of the oral microbiome is very complex and different in health and disease. Neutrophils are constantly recruited to the oral cavity, and their protective role is highlighted in cases where their number or functional responses are impeded, resulting in different forms of periodontal disease. Periodontitis, one of the more severe and irreversible forms of periodontal disease, is a microbial-induced chronic inflammatory disease that affects the gingival tissues supporting the tooth. This chronic inflammatory disease is the result of a shift of the oral bacterial symbiotic community to a dysbiotic more complex community. Chronic inflammatory infectious diseases such as periodontitis can occur because the pathogens are able to evade or disable the innate immune system. In this review, we discuss how human neutrophils interact with both the symbiotic and the dysbiotic oral community; an understanding of which is essential to increase our knowledge of the periodontal disease process.